Evidence map›Paper›PMID 40139525›Full record

ArticleJournal of advanced research2026

MdHMGB15-MdXERICO-MdNRP module mediates salt tolerance of apple by regulating the expression of salt stress-related genes.

Ran-Xin Liu, Shan-Shan Li, Qian-Yu Yue, Hong-Liang Li, Jie Lu, Wan-Cong Li, Yue-Ning Wang, Jia-Xing Liu, Xin-Long Guo, Xiang Wu and 3 more

Abstract read
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In one paragraph

Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Genome-Wide Identification and Expression Analysis of theInternational journal of molecular sciences · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ran-Xin LiuState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Shan-Shan LiState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Qian-Yu YueState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Hong-Liang LiState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Jie LuState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Wan-Cong LiState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Yue-Ning WangCollege of Horticulture Science, Gansu Agricultural University, Lanzhou 730070 Gansu, China.
Jia-Xing LiuState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Xin-Long GuoState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Xiang WuState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Ying-Xue LvState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China.
Xiao-Fei WangState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China. Electronic address: wangxiaofei@sdau.edu.cn.
Chun-Xiang YouState Key Laboratory of Wheat Improvement, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai-An 271018 Shandong, China. Electronic address: youchunxiang@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSoil salinity is an important limiting factor for plant growth. As a RING-type E3 ubiquitin ligase, MdXERICO is highly responsive to salt stress and can enhance the salt tolerance of plants. However, the molecular mechanism for the response of MdXERICO to salt stress remains unclear.

objectivesThis study aims to dissect the molecular mechanisms for MdXERICO to regulate plant response to salt stress.

methodsTranscriptome data were compared to obtain the salt stress-induced gene MdXERICO. Transgenic apple seedlings, apple calli, Arabidopsis, and tomato material were obtained using Agrobacterium-mediated transformation assays. Semiendogenous co-immunoprecipitation analysis, yeast two-hybrid, pull-down and dual-luciferase reporter system were used to detect the protein-protein interactions. Electrophoretic mobility shift assay, yeast one-hybrids, dual luciferase and Gus staining assay were employed to verify the protein-DNA interactions.

resultsThe results revealed that MdXERICO interacted with MdNRP and improved salt tolerance of apple by ubiquitinating and degrading MdNRP via the 26S proteasome pathway. Moreover, the HMG box-containing transcription factor MdHMGB15 interacted with the MdXERICO promoter, thereby activating its expression and enhancing the salt tolerance of apple.

conclusionThis study explores the apple's tolerance to salt stress through the MdHMGB15-MdXERICO-MdNRP module, and provides potential targets for engineering salt-tolerant varieties.

Indexed as

MalusSalt ToleranceUbiquitin-Protein LigasesGene Expression ProfilingGene Expression Regulation, PlantPlant ProteinsPlants, Genetically ModifiedReal-Time Polymerase Chain ReactionSalt StressSoilPlant ProteinsSoilUbiquitin-Protein LigasesAppleMdHMGB15MdNRP,MdXERICOSalt tolerance

Identifiers

PMID40139525
PMCPMC12766245

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.