Evidence map›Paper›PMID 40139339›Full record

ArticleProgress in neuro-psychopharmacology & biological psychiatry2025

Evidence for independent actions of the CRF and ghrelin systems in binge-like alcohol drinking in mice.

Rani S Richardson, Lindsay A Kryszak, Janaina C M Vendruscolo, George F Koob, Lorenzo Leggio, Leandro F Vendruscolo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in neuro-psychopharmacology & biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rani S RichardsonClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA; Neurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Stress and Addiction Neuroscience Unit, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA; University of North Carolina School of Medicine MD/PhD Program, University of North Carolina, Chapel Hill, NC, USA; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.
Lindsay A KryszakTranslational Analytical Core, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Janaina C M VendruscoloNeurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
George F KoobNeurobiology of Addiction Section, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse, Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA; Translational Analytical Core, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Providence, RI, USA; Division of Addiction Medicine, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA.. Electronic address: lorenzo.leggio@nih.gov.
Leandro F VendruscoloStress and Addiction Neuroscience Unit, Integrative Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, and National Institute on Alcohol Abuse and Alcoholism, Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore, MD, USA. Electronic address: leandro.vendruscolo@nih.gov.

Funding

Neurobiology of AddictionZIADA000602 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI KOOB, GEORGE · 2019 to 2025
$16.3M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
UNC Medical Scientist Training ProgramT32GM152316 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Toni Darville, Mohanish P Deshmukh · 2024 to 2026
$4.3M
Stress and Addiction Neuroscience UnitZIADA000644 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI VENDRUSCOLO, LEANDRO · 2023 to 2025
$4.1M
Intramural NIH HHS ZIA DA000602Intramural NIH HHS ZIA DA000635Intramural NIH HHS ZIA DA000644NIGMS NIH HHS T32 GM152316
6 · The paper itself

Abstract

Alcohol use disorder (AUD) and binge drinking are highly prevalent public health issues. Both ghrelin and corticotrophin-releasing factor (CRF) drive stress responses and alcohol drinking. Despite evidence of a relationship between the ghrelin and CRF systems, their potential interaction in modulating alcohol drinking is unclear. We tested the effect of a brain-penetrant CRF

Indexed as

Binge DrinkingCorticotropin-Releasing HormoneCRF Receptor, Type 1GhrelinAnimalsEthanolFemaleMaleMiceMice, Inbred C57BLPeptide FragmentsPyrimidinesReceptors, Corticotropin-Releasing HormoneReceptors, GhrelinastressinCorticotropin-Releasing HormoneCRF Receptor, Type 1EthanolGhrelinPeptide FragmentsPyrimidinesR 121919Receptors, Corticotropin-Releasing HormoneReceptors, GhrelinAddictionFeedingRewardStressSubstance use disorder

Identifiers

PMID40139339
PMCPMC12043401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.