Evidence map›Paper›PMID 40139293›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

Rapid slice-to-volume four-dimensional flow in pediatric congenital heart disease: a feasibility study.

Valérie Béland, Datta Singh Goolaub, Sharon Portnoy, Shi-Joon Yoo, Christopher Z Lam, Christopher K Macgowan

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Valérie BélandTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: valerie.beland@sickkids.ca.
Datta Singh GoolaubTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Sharon PortnoyTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Shi-Joon YooDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
Christopher Z LamDepartment of Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada.
Christopher K MacgowanTranslational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada; Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular magnetic resonance (CMR) allows cardiac hemodynamic assessment in patients with congenital heart disease (CHD). However, conventional techniques are time-consuming and may require blood contrast agents. Slice-to-volume reconstruction (SVR) four-dimensional (4D) flow is an innovative imaging technique that may overcome these limitations. This study aimed to assess the feasibility of SVR 4D flow in pediatric CHD.

methodsPatients with CHD (n=7, age=12.9±2.8years) underwent CMR with conventional two-dimensional (2D) phase-contrast magnetic resonance imaging (2D PCMRI) and SVR 4D flow. SVR 4D flow datasets were reconstructed from multi-slice 2D spiral PCMRI acquisitions, which were combined via slice-to-volume reconstruction. Mean flows in major thoracic vessels were measured and compared between the two techniques. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated for each participant and compared between imaging techniques.

resultsLinear regression for SVR 4D flow against 2D PCMRI showed good agreement for mean flows (slope=1.03, intercept=-5.31 mL/s, r

conclusionOur results suggest that SVR 4D flow CMR is a feasible 5-minute scan (relative to multiple 2D PCMRI prescriptions and scans) in pediatric patients with CHD. SVR 4D flow showed good agreement with 2D PCMRI for mean flow measurements. The advantages of SVR 4D flow support further research such as its comparison with conventional 4D flow.

Indexed as

Coronary CirculationHeart Defects, CongenitalHemodynamicsImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineMyocardial Perfusion ImagingAdolescentAge FactorsBlood Flow VelocityChildFeasibility StudiesFemaleHumansMagnetic Resonance ImagingMalePredictive Value of Tests4D flowCardiovascular imagingPediatricsSlice-to-volume reconstruction

Identifiers

PMID40139293
PMCPMC12182821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.