Evidence map›Paper›PMID 40139255›Full record

ArticleJournal of neurophysiology2025

Sex-related differences in motoneuron firing behavior during typical development.

Alexandra F Yacyshyn, Ghazaleh Mohammadalinejad, Babak Afsharipour, Jennifer Duchcherer, Jack Bashuk, David J Bennett, Francesco Negro, Katharina A Quinlan, Monica A Gorassini

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A question of rate? Girl-women differences in motor unit firing rate.European journal of applied physiology · 2026
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alexandra F YacyshynDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-9787-7225
Ghazaleh MohammadalinejadDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Babak AfsharipourDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Jennifer DuchchererDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0009-0001-6404-2803
Jack BashukDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
David J BennettFaculty of Rehabilitation Medicine, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0001-7838-7573
Francesco NegroDepartment of Clinical and Experimental Sciences, Universita degli Studi di Brescia, Brescia, Italy.ORCID 0000-0002-9094-8932
Katharina A QuinlanGeorge and Anne Ryan Institute for Neuroscience, Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States.ORCID 0000-0002-6177-4849
Monica A GorassiniDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-3079-6129

Funding

Impairment of Spinal Development in Cerebral PalsyR01NS104436 · NINDS · UNIVERSITY OF RHODE ISLAND · PI Katharina Ann Quinlan · 2017 to 2026
$4.3M
Canadian Government | CIHR | Institute of Neurosciences, Mental Health and Addiction (INMHA) 180430Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 05205Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC) 3475HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS10436NINDS NIH HHS R01 NS104436
6 · The paper itself

Abstract

Sex-related differences have been documented for intrinsic motoneuron excitability and firing rates in young adults, with females exhibiting higher excitability than males; however, it is unknown whether these parameters are affected by sex earlier in development. We compared the sex-related differences in firing behavior of single tibialis anterior (TA) motor units decomposed from high-density surface electromyography (EMG) in young (7-17 yr) and older (18-28 yr) developmental males and females during triangular dorsiflexion contractions at 10, 20, and 30% of their maximal voluntary contraction (MVC) torque. The amount of motoneuron self-sustained firing at estimated synaptic inputs below that needed for recruitment was measured [i.e., self-sustained firing (Δ

Indexed as

Action PotentialsMotor NeuronsMuscle, SkeletalSex CharacteristicsAdolescentAdultChildElectromyographyFemaleHumansMaleMuscle ContractionRecruitment, NeurophysiologicalYoung Adultfemalemalemotor unitsself-sustained firingtibialis anterior

Identifiers

PMID40139255
PMCPMC12163981

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.