Evidence map›Paper›PMID 40139221›Full record

ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2025

DIFENSE Study Protocol: Early Intervention With Difamilast Ointment in Infantile Early-Onset Atopic Dermatitis for Prevention of Transcutaneous Sensitisation.

Kiwako Yamamoto-Hanada, Kazuyoshi Okamoto, Nobuharu Kishimoto, Kunihiko Tsuchiya, Osamu Natsume, Yutaka Takemura, Masami Narita, Tohru Kobayashi, Yukihiro Ohya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prevention of Atopic Dermatitis: What Are We Missing?Allergy, asthma & immunology research · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kiwako Yamamoto-HanadaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1288-9620
Kazuyoshi OkamotoOtsuka Pharmaceutical Co., Ltd., Tokyo, Japan.
Nobuharu KishimotoOtsuka Pharmaceutical Co., Ltd., Tokyo, Japan.
Kunihiko TsuchiyaDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID https://orcid.org/0009-0008-3769-8832
Osamu NatsumeDepartment of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan.ORCID https://orcid.org/0000-0002-6892-6219
Yutaka TakemuraDepartment of Pediatrics, Kindai University, Faculty of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0002-0617-0532
Masami NaritaDepartment of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5862-679X
Tohru KobayashiDivision of Public Health, Jichi Medical University, Tochigi, Japan.ORCID https://orcid.org/0000-0002-7630-5367
Yukihiro OhyaAllergy Center, National Center for Child Health and Development, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1560-3942

Funding

Japan Agency for Medical Research and Development JP 23gn0110078s020Japan Agency for Medical Research and Development JP24ek0410104h0002Japan Agency for Medical Research and Development JP24hk010299j0001Otsuka Pharmaceutical
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

atopic dermatitisdifamilastfood allergypreventionproactive therapysensitisation

Identifiers

PMID40139221
PMCPMC12221857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.