Evidence map›Paper›PMID 40138707›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Fungal-derived methyldeoxaphomins target

Tiantian Jiang, Jin Woo Lee, Jennifer E Collins, Samuel Schaefer, Daisy Chen, Flore Nardella, Karen Wendt, Thilini G Peramuna, Raphaella Paes, James L McLellan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tiantian Jiang *Department of Pediatrics, School of Medicine, University of California, San Diego, CA 92093.ORCID 0000-0002-4875-3613
Jin Woo Lee *College of Pharmacy, Duksung Women's University, Seoul 01369, Republic of Korea.ORCID 0000-0002-0573-0884
Jennifer E Collins *Division of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826.
Samuel SchaeferDepartment of Pediatrics, School of Medicine, University of California, San Diego, CA 92093.
Daisy ChenDepartment of Pediatrics, School of Medicine, University of California, San Diego, CA 92093.
Flore NardellaDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826.
Karen WendtDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
Thilini G PeramunaDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
Raphaella PaesDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826.ORCID 0000-0002-6146-5309
James L McLellanDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249.
Jasveen BhasinDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826.ORCID 0009-0001-3503-3326
Gregory L DurstLgenia Inc., Fortville, IN 46040.ORCID 0009-0009-7188-1347
Kirsten K HansonDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249.ORCID 0000-0002-0154-0979
Debopam ChakrabartiDivision of Molecular Microbiology, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32826.ORCID 0000-0002-4554-3119
Robert H CichewiczDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109.
Elizabeth A WinzelerDepartment of Pediatrics, School of Medicine, University of California, San Diego, CA 92093.

Funding

Novel Antimalarials from FungiR01AI154777 · NIAID · UNIVERSITY OF CENTRAL FLORIDA · PI CHAKRABARTI, DEBOPAM, CICHEWICZ, ROBERT HENRY · 2020 to 2024
$3.8M
Discovery of long-acting, chemoprotective antimalarial compoundsR01AI152533 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2020 to 2024
$3.5M
Discovery of chemically validated malaria liver stage targetsR01AI090141 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WINZELER, ELIZABETH A · 2011 to 2019
$3.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Bill and Melinda Gates Foundation (GF) INV-039628NIAID NIH HHS R01 AI090141NIAID NIH HHS R01 AI152533NIAID NIH HHS R01 AI154777NIH HHS S10 OD026929
6 · The paper itself

Abstract

Herein we report the finding and structure determination of a natural product based on the methyldeoxaphomin scaffold family from the fungus

Indexed as

Adenosine TriphosphatasesAntimalarialsHypocrealesPlasmodium falciparumProtozoan ProteinsHumansMolecular Docking SimulationStructure-Activity RelationshipAdenosine TriphosphatasesAntimalarialsProtozoan Proteinsfungi-derived natural productmethyldeoxaphominPlasmodium falciparum

Identifiers

PMID40138707
PMCPMC11874377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.