Evidence map›Paper›PMID 40138521›Full record

ArticleKidney3602025

Tubule-Specific Compensatory Responses to Cpt1a Deletion in Aged Mice.

Steven D Funk, Justin T Kern, Olga M Viquez, Elizabeth Sulvaran-Guel, Jeffrey R Koenitzer, Kyle C Feola, Jacob S Blum, Roy Zent, Benjamin D Humphreys, Sarah C Huen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney360, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Steven D FunkDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-8261-6268
Justin T KernDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0009-0008-8219-7623
Olga M ViquezDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0009-0005-6155-0561
Elizabeth Sulvaran-GuelDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-6288-5516
Jeffrey R KoenitzerDivision of Pulmonary Critical Care Medicine, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-4556-8455
Kyle C FeolaDepartment of Internal Medicine (Nephrology) and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0002-1190-9696
Jacob S BlumDepartment of Radiology, Stanford University, Stanford, California.ORCID 0000-0002-4156-4094
Roy ZentDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0003-2983-8133
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-6420-8703
Sarah C HuenDepartment of Internal Medicine (Nephrology) and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas.ORCID 0000-0001-6420-2400
Leslie S GewinDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.ORCID 0000-0002-6146-1092

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
Structure and Function of Integrins in the KidneyR01DK088327 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ARNAOUT, M. AMIN · 2010 to 2025
$5.3M
Washington University Chronic KidneyDisease National Resource CenterU54DK137332 · NIDDK · WASHINGTON UNIVERSITY · PI BENJAMIN D. HUMPHREYS · 2023 to 2026
$4.5M
UAB-UCSD O'Brien Center for Acute Kidney Injury ResearchU54DK137307 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Javier A. Neyra · 2023 to 2026
$4.4M
Understanding Myofibroblast Progenitor Fate and Function in Renal FibrosisR01DK103740 · NIDDK · WASHINGTON UNIVERSITY · PI BENJAMIN D. HUMPHREYS · 2015 to 2026
$3.9M
TGF-beta Pathways that Protect Epithelia in Chronic Renal InjuryR01DK108968 · NIDDK · WASHINGTON UNIVERSITY · PI GEWIN, LESLIE S · 2016 to 2025
$3.7M
Single-cell analysis to promote kidney repairUC2DK126024 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D., KIM, JUNHYONG · 2020 to 2024
$3.7M
Prune Belly Syndrome: Mechanisms of Filamin A MutationsR01DK127589 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI BAKER, LINDA A., QIN, JUN · 2020 to 2024
$2.5M
Harnessing Fasting Metabolism to Improve Survival in Bacterial SepsisR35GM137984 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HUEN, SARAH · 2020 to 2024
$2.2M
Defining intra-renal ketone metabolism in kidney health and diseaseR01DK135555 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI sarah huen · 2024 to 2026
$1.8M
Microfibril-associated glycoproteins attenuating pulmonary fibrosisK08HL159418 · NHLBI · WASHINGTON UNIVERSITY · PI Jeffrey Koenitzer · 2022 to 2026
$857k
BLRD VA I01 BX002196BLRD VA I01 BX003425NHLBI NIH HHS K08 HL159418NIDDK NIH HHS 1U54DK137332NIDDK NIH HHS 5K08HL159418-03NIDDK NIH HHS DK069921NIDDK NIH HHS DK088327NIDDK NIH HHS DK127589NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK088327NIDDK NIH HHS R01 DK103740NIDDK NIH HHS R01 DK108968NIDDK NIH HHS R01DK108968NIDDK NIH HHS R01 DK127589NIDDK NIH HHS R01 DK135555NIDDK NIH HHS R01DK135555NIDDK NIH HHS R35GM137984NIDDK NIH HHS R56 DK134582NIDDK NIH HHS R56DK134582NIDDK NIH HHS U54 DK137307NIDDK NIH HHS U54 DK137332NIDDK NIH HHS UC2 DK126024NIDDK NIH HHS UC2DK126024NIGMS NIH HHS R35 GM137984US Department of Veterans Affairs BX002196US Department of Veterans Affairs BX03425
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

metabolismproximal tubule

Identifiers

PMID40138521
PMCPMC12136631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.