Evidence map›Paper›PMID 40138446›Full record

Observational studyAnnals of medicine2025

Pharmacogenomic heterogeneity of

Levin Thomas, Chaithra, Yashi Batra, Mitali Mathur, Shrivathsa Kulavalli, Chidananda Sanju Sv, Naveen Dutt, Pankaj Bhardwaj, Muralidhar Varma, Kavitha Saravu and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Intrathecal Isoniazid and Dexamethasone Therapy May Improve Outcomes in Patients With Tuberculous Meningitis: A 2-Center Retrospective Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Levin ThomasDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
ChaithraDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
Yashi BatraDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Mitali MathurDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Shrivathsa KulavalliDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
Chidananda Sanju SvDistrict Tuberculosis Control Office, Udupi, India.
Naveen DuttDepartment of Pulmonary Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Pankaj BhardwajDepartment of Community Medicine and Family Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Muralidhar VarmaDepartment of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.
Kavitha SaravuDepartment of Infectious Diseases, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, India.ORCID 0000-0001-6399-1129
Mithu BanerjeeDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Mahadev RaoDepartment of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIsoniazid is primarily metabolized by the arylamine PATIENTS AND

methodsWe conducted a prospective observational study to characterize and compare the

resultsThe TB patients of Southern and Western regions of India and several other geographically closer regions exhibited near similar

conclusionFurther studies exploring the risk of

Indexed as

Antitubercular AgentsArylamine N-AcetyltransferaseChemical and Drug Induced Liver InjuryIsoniazidTuberculosisAdultFemaleGenotypeHumansIndiaMaleMiddle AgedPharmacogeneticsPhenotypePolymorphism, Single NucleotideProspective StudiesAntitubercular AgentsArylamine N-AcetyltransferaseIsoniazidNAT2 protein, humanAT-DILIIsoniazidN-acetyltransferase 2pharmacogenomicssingle nucleotide polymorphism

Identifiers

PMID40138446
PMCPMC11948353

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.