ArticleScience advances2025
Pregnancy and postpartum dynamics revealed by millions of lab tests.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prevalence of mental health-related multimorbidity during pregnancy: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Impact of oral iron dosing regimens on iron biomarkers during pregnancy: insights from the PANDA trial.Blood advances · 2026Trial
- Longitudinal modelling of microbiome subcommunities reveals parity-dependent dynamics during pregnancy and postpartum.Gut microbes · 2026Article
- Critical Appraisal of Personalized Reference Intervals.International journal of laboratory hematology · 2026Article
- Quantification of beta-cell carrying capacity in prediabetes.PLoS computational biology · 2026Article
- Maternal biological aging from pregnancy through four years postpartum with disrupted recovery by subsequent pregnancy.iScience · 2026Article
- FGF21 and SHBG as Putative Hepatic Axes in Maternal Metabolic Adaptation: A Hypothetical Framework for Postpartum Insulin Sensitivity Restoration.Biomolecules · 2026Review
- Associations of preconception retinal microvasculature with lipid profiles from mid-pregnancy to three months postpartum.NPJ cardiovascular health · 2026Article
- Associations between hematologic dynamics during pregnancy and obstetric complications: A retrospective observational study.PLoS medicine · 2026Observational
- Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis.Nature aging · 2026Article
- Pregnancy lab test dynamics resemble rejuvenation of some organs and aging of others.Nature communications · 2026Article
- Dense sampling for mapping pituitary growth dynamics before, during, and after pregnancy.Journal of neuroendocrinology · 2026Article
- TidyMass2: advancing LC-MS untargeted metabolomics through metabolite origin inference and metabolic feature-based functional module analysis.Nature communications · 2026Article
- Editorial: Impact of physical activity on women's health and quality of life: focusing on maternal health and pregnancy outcomes.Frontiers in sports and active living · 2026Article
- Diurnal cortisol trajectories from mid-pregnancy to one year after birth.Psychoneuroendocrinology · 2026Article
- Unifying regulatory motifs in endocrine circuits.Nature communications · 2025Article
- The Gut Microbiome and Emotional Distress During Pregnancy: Shaking the Foundations of Future Mental Health?Biological psychiatry global open science · 2025Article
- Harnessing huge data from pregnancy natural experiments.Science advances · 2025Review
- Previous parity differentially influences cognition in later life depending on dementia status.NPJ dementia · 2025Article
- Maternal and fetal outcomes in 151 cases of thrombocytopenia in pregnancy.Frontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy and delivery involve dynamic alterations in many physiological systems. However, the physiological dynamics during pregnancy and after delivery have not been systematically analyzed at high temporal resolution in a large human population. Here, we present the dynamics of 76 lab tests based on a cross-sectional analysis of 44 million measurements from over 300,000 pregnancies. We analyzed each test at weekly intervals from 20 weeks preconception to 80 weeks postpartum, providing detailed temporal profiles. About half of the tests take 3 months to a year to return to baseline postpartum, highlighting the physiological load of childbirth. The precision of the data revealed effects of preconception supplements, overshoots after delivery and intricate temporal responses to changes in blood volume and renal filtration rate. Pregnancy complications-gestational diabetes, preeclampsia, and postpartum hemorrhage-showed distinct dynamical changes. These results provide a comprehensive dynamic portrait of the systems physiology of pregnancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.