ArticleScience advances2025
Assessing cancer therapeutic efficacy in vivo using [
Abstract read
In one paragraph
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Deuterated Molecular Probes for Metal Sensing.ACS omega · 2026Article
- On the Origin of the Brain Semi-Heavy Water Deuterium MR Signal Following Administration of Deuterated Metabolic Substrate: A Cautionary Tale.Magnetic resonance in medicine · 2026Article
- Deuterium metabolic imaging beyond the brain: mapping tissue metabolism across the body.Magma (New York, N.Y.) · 2026Review
- Assessing the treatment of pancreatic ductal adenocarcinoma by deuterium metabolic imaging: a preclinical study.Magma (New York, N.Y.) · 2026Article
- Deuterated pH Probes Based on Ketoglutarate for Magnetic Resonance.Journal of the American Chemical Society · 2026Article
- Enzyme-Activated MRI for In Vivo Glucose Imaging via a Biodegradable Chromium Nanoprobe.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Review
- Uridine-Based PET/NIRF Dual-Modality imaging for precision tumor diagnosis and surgery.European journal of nuclear medicine and molecular imaging · 2026Article
- Early Detection of Chemotherapy-Induced Glucose Metabolic Alterations in Bladder Carcinoma Using Deuterium (Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Advancing Deuterium MRI to Track Human Cerebral Glucose Metabolism at 7 T: A Comparison of Glucose-dNMR in biomedicine · 2025Article
- Probing Intracellular Yeast Metabolism With Deuterium Magnetic Resonance Spectroscopy.NMR in biomedicine · 2025Article
- Metabolic flux analysis of glioblastoma neural stem cells reveals distinctive metabolic phenotypes in ketogenic conditions.Scientific reports · 2025Article
- Metabolic plasticity drives specific mechanisms of chemotherapy and targeted therapy resistance in metastatic colorectal cancer.Exploration of targeted anti-tumor therapy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Mario C ChangDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-2452-2693
Vinay R MalutDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Rohit MaharDepartment of Chemistry, Hemvati Nandan Bahuguna Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand 246174, India.ORCID 0000-0002-9801-4173
Anna RushinDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0002-5643-0101
Marc A McLeodCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Geraldine L PierreDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0000-0573-8440
Indu R MalutDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Stephen J StaklinskiSchool of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.ORCID 0000-0002-1746-6320
Max E GlanzDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0007-9724-478X
Mukundan RagavanDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-8678-4229
Gaurav SharmaDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0002-3832-0897
Manoj MadheswaranDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0005-9642-571X
Arshee BadarDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0009-0007-0182-8968
Aparna D RaoPeter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.ORCID 0000-0002-6394-0011
Brian K LawDepartment of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, 32610, USA.ORCID 0000-0002-8411-6531
Michael S KilbergDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
James H P CollinsNational High Magnetic Field Laboratory, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-4333-3748
Vikram D KodibagkarSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85281, USA.ORCID 0000-0003-1933-8821
James A BanksonDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-8574-154X
Ralph J DeBerardinisCenter for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2705-7432
Matthew E MerrittDepartment of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, FL 32610, USA.ORCID 0000-0003-4617-9651
Funding
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN · 2022 to 2026
$7.4MHDO Imaging is a Quantitative Marker of Cerebral Glucose OxidationR01EB032376 · NIBIB · UNIVERSITY OF FLORIDA · PI BANKSON, JAMES A, KODIBAGKAR, VIKRAM D. · 2022 to 2025
$2.2MImaging Hepatic Energy Metabolism in NAFLD/NASHR01DK132254 · NIDDK · UNIVERSITY OF FLORIDA · PI MERRITT, MATTHEW E · 2022 to 2025
$2.0MInterdisciplinary Graduate Program in Type 1 Diabetes and Biomedical EngineeringT32DK108736 · NIDDK · UNIVERSITY OF FLORIDA · PI MARK A. ATKINSON, Benjamin George Keselowsky · 2017 to 2026
$1.9MMeasuring Exocrine Pancreas Metabolism in Type 1 DiabetesF31DK138741 · NIDDK · UNIVERSITY OF FLORIDA · PI NULK, ANNA RUSHIN · 2024 to 2025
$75kNIBIB NIH HHS R01 EB032376NIDDK NIH HHS F31 DK138741NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK132254NIDDK NIH HHS T32 DK108736
Abstract
Metabolic imaging produces powerful visual assessments of organ function in vivo. Current techniques can be improved by safely increasing metabolic contrast. The gold standard, 2-[
Indexed as
DeuteriumGlucoseMagnetic Resonance ImagingNeoplasmsAnimalsCell Line, TumorFemaleHumansMicePositron-Emission TomographyXenograft Model Antitumor AssaysDeuteriumGlucose
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.