Evidence map›Paper›PMID 40138411›Full record

ArticleScience advances2025

Systemic antitumor immune response of doped yttria nanoscintillators under low-dose x-ray irradiation.

Onur Sahin, Yuri Mackeyev, Geraldine V Vijay, Soumyabrata Roy, Ashokkumar Meiyazhagan, Yasmin Zahra, Okan Tezcan, Valeria Gonzalez, Belal Abousaida, Holden R Wagner and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Onur SahinDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0003-2191-5659
Yuri MackeyevDepartment of Neurosurgery, McGovern Medical School at UTHealth Houston, Houston, TX 77030, USA.ORCID 0000-0003-4456-0563
Geraldine V VijayDepartment of Neurosurgery, McGovern Medical School at UTHealth Houston, Houston, TX 77030, USA.ORCID 0000-0002-4644-3080
Soumyabrata RoyDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0003-3540-1341
Ashokkumar MeiyazhaganDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0002-9765-4347
Yasmin ZahraDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL 32224 USA.ORCID 0000-0003-4419-652X
Okan TezcanDepartment of Neurosurgery, McGovern Medical School at UTHealth Houston, Houston, TX 77030, USA.
Valeria GonzalezDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL 32224 USA.ORCID 0000-0002-5747-1298
Belal AbousaidaDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL 32224 USA.ORCID 0000-0001-5418-5221
Holden R WagnerDepartment of Neurosurgery, McGovern Medical School at UTHealth Houston, Houston, TX 77030, USA.ORCID 0000-0001-8718-6474
Pearl FernandesDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0002-3452-9661
Riaz Mowzoon-MogharrabiDepartment of Chemistry, University of California, Berkley, Berkley, CA 94720, USA.ORCID 0000-0003-3495-9968
Bhanu P VenkatesuluDepartment of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Cheng-En HsiehDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.ORCID 0000-0002-2038-4537
Joseph B K KimDepartment of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL 32224 USA.
Subhiksha RaghuramDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xiang ZhangDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0003-4004-5185
Kristen A MillerDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0002-5694-3169
Guanhui GaoDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.ORCID 0000-0002-4760-1378
Pankaj K SinghDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sang Hyun ChoDivision of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Rao V L PapineniPACT & Health LLC, Branford, CT 06405, USA.ORCID 0000-0002-1263-4292
Pulickel M AjayanDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.
Sunil KrishnanDepartment of Neurosurgery, McGovern Medical School at UTHealth Houston, Houston, TX 77030, USA.ORCID 0000-0002-1340-4771

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3M
Rational translation of gold nanoparticle mediated radiosensitization tothe clinicR01CA257241 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Sang Hyun Cho, Sunil Krishnan · 2021 to 2026
$3.1M
Enhancing immune mediated head and neck cancer anti-tumor activity using nanoparticlesR01DE028105 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KRISHNAN, SUNIL, SKINNER, HEATH DEVIN · 2019 to 2023
$2.4M
Radiation response modulation of tumors using biocongjugated gold nanoparticlesR01CA155446 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHO, SANG HYUN, KRISHNAN, SUNIL · 2011 to 2015
$1.5M
Topic 394 - A versatile radiation-triggered phosphor platform for localized anti-cancer therapy75N91019C00016 · NCI · PACT AND HEALTH, LLC · PI PAPINENI, RAO · 2019 to 2019
$300k
NCI NIH HHS 75N91019C00016NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA155446NCI NIH HHS R01 CA257241NIDCR NIH HHS R01 DE028105
6 · The paper itself

Abstract

Inadequate light penetration in tissues restricts photodynamic therapy to treating only superficial tumors. To enable x-ray-excited photodynamic therapy (XPDT) that targets deep-seated tumors, we synthesized a nanoscintillator-photosensitizer complex containing 5% Eu-doped Y

Indexed as

Photosensitizing AgentsYttriumAnimalsCell Line, TumorHumansMethylene BlueMicePhotochemotherapySilicon DioxideXenograft Model Antitumor AssaysX-RaysMethylene BluePhotosensitizing AgentsSilicon DioxideyttriaYttrium

Identifiers

PMID40138411
PMCPMC11939067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.