ArticleProceedings of the National Academy of Sciences of the United States of America2025
Allosteric mechanism in the distinctive coupling of G
Xuan Zhang, Ji Young Lee, Jonathan Pacheco, Ieva Sutkeviciute, Anju Krishnan Anitha, Heng Liu, Stephanie Singh, Carlos Ventura, Sofya Savransky, Ashok Khatri and 3 more
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 · What the graph read from it
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5 · Who and what money
Authors and funding
13 authors.
Xuan Zhang *Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-4276-6464
Ji Young Lee *Laufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.
Jonathan Pacheco *Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Ieva SutkeviciuteDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Anju Krishnan AnithaEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Heng LiuDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Stephanie SinghDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Carlos VenturaLaufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.
Sofya SavranskyDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Ashok KhatriEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0001-9042-4007
Ivet BaharLaufer Center for Physical and Quantitative Biology, Stony Brook University, New York, NY 11794.ORCID 0000-0001-9959-4176
Jean-Pierre VilardagaDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-1217-1435
Funding
Structure and function of PTH class B GPCRR01DK116780 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar, Jean-Pierre Vilardaga · 2018 to 2026
$4.2M
Toward a Deeper Understanding of Allostery and Allotargeting by Computational ApproachesR01GM139297 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ivet Bahar · 2021 to 2026
$2.8M
Regulation of Parathyroid Functions By G-Protein Coupled ReceptorsR01DK122259 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI CHANG, WENHAN, VILARDAGA, JEAN-PIERRE · 2019 to 2023
$2.2M
Structural and Functional Mechanisms of PTH-Receptor SignalingR01DK102495 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO, GARDELLA, THOMAS J · 2014 to 2017
$2.0M
Predoctoral Training in Pharmacological Sciences (Resubmission)T32GM133332 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tija C. Jacob, Francisco Jose Schopfer · 2020 to 2026
$1.8M
The role of cell surface glycosaminoglycans (GAGs) in PTHrP bias signalingF31DK136222 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAVRANSKY, SOFYA · 2024 to 2025
The mechanism determining the preferential stimulation of one heterotrimeric G protein signaling pathway over another by a ligand remains undetermined. By reporting the cryogenic electron microscopy (cryo-EM) structure of the parathyroid hormone (PTH) type 1 receptor (PTH1R) complexed with Gq and comparing its allosteric dynamics with that of PTH1R in complex with G
Indexed as
GTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsReceptor, Parathyroid Hormone, Type 1Allosteric RegulationBinding SitesCryoelectron MicroscopyHEK293 CellsHumansKineticsLigandsParathyroid HormoneProtein BindingSignal TransductionGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein alpha Subunits, GsLigandsParathyroid HormonePTH1R protein, humanReceptor, Parathyroid Hormone, Type 1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Allosteric mechanism in the distinctive coupling of G · full record | OpenQuestion