ArticlePloS one2025
Impact of lufenuron on hematology, serum biochemistry, antioxidant enzymes, and histopathology in broiler chickens.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Assessment of risks associated with dietary administration of antiparasitic drug lufenuron in Nile tilapia Oreochromis niloticus by integrated biomarker response.Veterinary research communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The widespread utilization of synthetic chemicals, including weedicides, pesticides, insecticides, and fertilizers, has contaminated the environment. Therefore, it is crucial to recognize the ongoing threat of various stressors, including exposure to synthetic and natural chemicals on various target and non-target living organisms. Lufenuron is extensively utilized in controlling ectoparasites in companion animals and may offer a potential solution for addressing analogous challenges in commercial poultry farming. For this purpose, an experimental study was conducted to estimate the potential toxic effects of lufenuron in chickens. A total of 75 broiler chickens were housed under standard environmental conditions for the period of 39 days following a 7-day acclimatization. Birds were randomly divided into five groups (A-E), each consisting of 15 birds, and administered different doses of lufenuron in groups B-E @ 4, 8, 12, and 16 mg/kg body mass, respectively. Various hematological, biochemical, and histopathological biomarkers were assessed in blood and visceral organs. In the current experimental trial, the values of RBC count, PCV, hemoglobin, and MCHC significantly (<0.05) decreased, while WBCs and MCH significantly (<0.05) increased in treated birds. Results showed significantly increased values of renal function tests (urea and creatinine), liver function tests (ALP, AST, and ALT), and cardiac biomarkers (cholesterol and creatinine kinase) in broilers exposed to higher doses of lufenuron. Various histopathological ailments were examined in the liver, kidneys, and heart of the broiler in the dose and time-dependent manner. The current study showed that lufenuron induces oxidative stress, depletion of various antioxidant enzymes, and histoarchitectural alterations in multiple visceral organs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.