Evidence map›Paper›PMID 40138166›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025

Trace elements and cognitions in elderly population: a case-control study.

Anil Kumar Maurya, Mona Srivastava, Ashish Ashish, Nitish Kumar Singh, Abhay Kumar Yadav, Shani Vishwakarma, Royana Singh

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anil Kumar MauryaDepartment of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Mona SrivastavaDepartment of Psychiatry, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Ashish AshishMultidisciplinary Research Unit, ICMR DHR, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Nitish Kumar SinghMultidisciplinary Research Unit, ICMR DHR, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Abhay Kumar YadavDepartment of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Shani VishwakarmaDepartment of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India.
Royana SinghDepartment of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, Varanasi, 221005, India. royanasingh@bhu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been almost no studies with trace elements and psychological battery in cognitively impaired elderly individuals. Such research is crucial to enhance diagnostic accuracy. We aim to identify significant differences in blood serum concentration levels of trace elements, Hindi Mini-Mental State Examination (HMMSE), and psychological battery as Hindi Mattis Dementia Rating Scale (HMDRS) scores between case and control groups in the elderly. A cross-sectional research design was conducted with a total of 240 subjects, comprising 120 each from the case and control groups. Trace elements were analyzed using Atomic Absorption Spectrometry. HMMSE and HMDRS tests were administered to assess cognition scores. The chi-square test, t-test, and appropriate statistics were utilized. Our findings indicate significant differences in demographic factors (age, gender, education level) and clinical levels (p < .001), while caste, habitat, and marital status were not significant (p < .05). Concentration levels of Iron (Fe) and Copper (Cu) was higher, Zinc (Zn), Chromium (Cr), and Selenium (Se) were lower, significantly different (p < .001), but Magnesium (Mg) was not (p < .05). Additionally, third HMMSE and HMDRS were significant (p < .001) between the case and control groups in the elderly. The study suggested that higher levels of Fe and Cu, while lower Zn, Cr, and Se blood serum concentrations increased the risk of cognitive impairments in the elderly population, demonstrated by the HMMSE and HMDRS test scores which were lower in the case group.

Indexed as

CognitionTrace ElementsAgedAged, 80 and overCase-Control StudiesCross-Sectional StudiesFemaleHumansIronMaleMiddle AgedSeleniumIronSeleniumTrace ElementsCognitionDementiaHMDRSHMMSETrace elements

Identifiers

PMID40138166

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