Evidence map›Paper›PMID 40138120›Full record

ReviewMolecular neurobiology2025

Melatonin Interventions in Autism Spectrum Disorder: Sleep Regulation, Behavioral Outcomes, and Challenges Across the Lifespan.

Geir Bjørklund, Oleksandra Oleshchuk, Yana Ivankiv, Olena Venger, Olha Liuta, Khrystyna Mocherniuk, Mariana Lukanyuk, Mariia Shanaida

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo I Rana, Norway. bjorklund@conem.org.
Oleksandra OleshchukI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Yana IvankivI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Olena VengerI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Olha LiutaI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Khrystyna MocherniukI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Mariana LukanyukI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Mariia ShanaidaI. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) poses complex challenges affecting social interaction, communication, and behavior, necessitating comprehensive and tailored interventions. Sleep disturbances, prevalent in up to 80% of individuals with ASD, significantly impact well-being. Central to circadian rhythms, melatonin emerges as a promising intervention, primarily recognized for its role in sleep regulation. This review explores melatonin's multifactor impact on ASD, covering sleep regulation, behavioral outcomes, neuroprotection, and potential synergies with other therapies. Melatonin exhibits promise in ameliorating sleep disturbances and enhancing overall well-being, with implications for social behaviors, communication, and repetitive behaviors. Its antioxidant and anti-inflammatory properties further suggest potential neuroprotective benefits. Future research directions focus on mechanistic insights, individualized medicine, and real-world effectiveness. As melatonin's versatile role unfolds, it stands as a valuable component in the personalized care of individuals navigating the complexities of ASD.

Indexed as

Autism Spectrum DisorderLongevityMelatoninSleepAnimalsHumansTreatment OutcomeMelatoninAdolescentsAdultsAnti-inflammatory activityAntioxidant effectAutismBehavioral outcomesChallengesCircadian rhythmsDosagesIndividualized medicineMelatoninNeuroprotectionSleep disturbances

Identifiers

PMID40138120

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.