Evidence map›Paper›PMID 40138031›Full record

ArticleNeurosurgical review2025

Extended endoscopic endonasal approach for solid or predominantly solid third ventricle craniopharyngiomas complicated with obstructive hydrocephalus: a single-center experience of 27 patients.

Ning Qiao, Chuzhong Li, Xin Liu, Yifan Song, Lihong Liang, Yixin Zou, Pengwei Lu, Yazhuo Zhang, Songbai Gui

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Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ning QiaoDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Chuzhong LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Xin LiuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Yifan SongDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Lihong LiangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Yixin ZouDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Pengwei LuDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Yazhuo ZhangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China.
Songbai GuiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Beijing, 100070, China. guisongbai@yeah.net.

Funding

Beijing Hospitals Authority Youth Programme QML-20230516National Natural Science Foundation of China 82272168
6 · The paper itself

Abstract

objectiveDirect surgical resection may be the only choice for solid or predominantly solid third ventricle craniopharyngiomas (TVCs) complicated with hydrocephalus. Despite the increased use of the extended endoscopic endonasal approach (EEEA), the viewpoint that these tumors are unsuitable for endonasal resection remains prevailing. This paper presents the largest case series assessing the surgical outcomes of EEEA for solid or predominantly solid TVCs complicated by hydrocephalus.

methodsWe retrospectively analyzed the data of 27 patients newly diagnosed with solid or predominantly solid TVCs complicated with hydrocephalus treated by EEEA.

resultsGross total resection (GTR) was achieved in 88.9% of 27 patients. The rate of hydrocephalus relief was 100%, with an average Evans' index decrease of 0.05 and a simplified callosal angle increase of 15.8°. The mean Mini-Mental State Examination score improved significantly in the strictly TVC group after surgery (p = 0.03) but not in the infundibulo-tuberal TVC group (p = 0.61). Postoperative visual worsening occurred in 11.1% of patients. New-onset hypopituitarism was observed in 62.9% of patients. Permanent diabetes insipidus occurred in 63.0% of patients. New-onset obesity was noted in 17.4%. During a mean follow-up of 38.9 months (range 12.9-67.9 months), tumor recurrence and mortality rates were 11.1% and 0%, respectively.

conclusionsThe EEEA could be a safe and effective choice for solid or predominantly solid TVCs complicated with obstructive hydrocephalus, offering a higher rate of GTR and a lower rate of newly developed postoperative hydrocephalus. Intraoperative VEP monitoring may be necessary to minimize the risk of postoperative visual deterioration.

Indexed as

CraniopharyngiomaHydrocephalusNeuroendoscopyPituitary NeoplasmsThird VentricleAdolescentAdultAgedChildFemaleHumansMaleMiddle AgedNeurosurgical ProceduresPostoperative ComplicationsRetrospective StudiesBRAF V600E mutationExtended endoscopic endonasal approachHydrocephalusPapillary craniopharyngiomaSolid tumorThird ventricle craniopharyngioma

Identifiers

PMID40138031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.