Evidence map›Paper›PMID 40138023›Full record

ArticleMolecular biology reports2025

MALAT1 SNP (rs619586) shows a protective effect against type 1 diabetes mellitus, while the miR-146a SNP (rs57095329) is linked to an increased risk of developing the disease.

Soha M Hamdy, Heba A Ibrahim, Omayma O Abdelaleem, Olfat G Shaker, Sherin K Hussein, Sara M A K Massoud, Ola N Sayed

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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6citing papers in PubMed
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6 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Soha M HamdyDepartment of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt.
Heba A IbrahimDepartment of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt.
Omayma O AbdelaleemDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt. dr.omayma@yahoo.com.ORCID http://orcid.org/0000-0003-2881-6776
Olfat G ShakerDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Sherin K HusseinDepartment of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Sara M A K MassoudDepartment of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt.
Ola N SayedDepartment of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 1 diabetes mellitus (T1DM), one of the most distinct and intricate metabolic diseases, is characterized by the death of pancreatic β-cells, which leads to a lack of insulin secretion and, ultimately, hyperglycemia. The condition is more common in children and adolescents. Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) regulate gene expression at the post-transcriptional level. They are essential to the control of several vital physiological processes. Many diseases have been linked to genetic variations in LncRNAs and miRNAs, though, their significance in type 1 diabetes mellitus (T1DM) is yet underappreciated.

methodsNinety-two Egyptian children diagnosed with T1DM as well as 92 healthy age- and sex-matched subjects were incorporated in the current research. Real-time polymerase chain reaction (RT-PCR) was used to assess rs619586 and rs57095329 in the study subjects.

resultsThe GG and AG genotypes and the G allele of MALAT1 (rs619586) were associated with a significant decrease in the risk of T1DM.Also, the AG and GG genotypes as well as the G allele of miR-146a (rs57095329) were associated with a significant increase in the risk of T1DM (p > 0.05, each).

conclusionFor the first time, our investigation had shown the connection between MALAT1 (rs619586) and miRNA-146a (rs57095329) polymorphisms and the risk of development of T1DM in Egyptians.

Indexed as

Diabetes Mellitus, Type 1MicroRNAsPolymorphism, Single NucleotideRNA, Long NoncodingAdolescentAllelesCase-Control StudiesChildChild, PreschoolEgyptFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleRisk FactorsMALAT1 long non-coding RNA, humanMicroRNAsMIRN146 microRNA, humanRNA, Long Noncodingrs57095329rs619586T1DM

Identifiers

PMID40138023

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