Mucoepidermoid Carcinoma Associated with an Intercalated Duct Lesion: Precursor or Coincidence?

Joshua S Goldfaden, Seungwon Kim, Raja R Seethala

Abstract readCase Reports

In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Imaging of benign salivary gland tumors under the fifth WHO classification, with a focus on rare histologic types and newly listed entities-Part II.Japanese journal of radiology · 2026
Review
Caught in the Act: Intercalated Duct Lesion Associated with Adenoid Cystic Carcinoma Harboring a MYBL1::NFIB Fusion.Head and neck pathology · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Joshua S GoldfadenOral and Maxillofacial Pathology Resident, Department of Diagnostic Sciences, School of Dental Medicine, University of Pittsburgh, G-132 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA. jsg114@pitt.edu.

Seungwon KimDepartment of Otolaryngology, University of Pittsburgh, #300 Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Raja R SeethalaDepartment of Otolaryngology, University of Pittsburgh, #300 Presbyterian University Hospital, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMucoepidermoid carcinoma (MEC) typically occurs in isolation. We report an unusual case of MEC coexisting with an intercalated duct lesion (IDL), both harboring MAML2 rearrangements. CASE PRESENTATION: An 82-year-old male with a left parotid mass underwent superficial parotidectomy.

methodsMicroscopic examination of immunohistochemical stains and fluorescence in situ hybridization (FISH) studies were performed.

resultsThe parotid demonstrated an intermediate grade MEC and an adjacent IDL with the typical abluminal ΔNp63 (p40) and ductal SOX-10 immunopositivity, but absent LEF-1 and nuclear β-catenin staining. FISH confirmed MAML2 rearrangements in both lesions.

conclusionThis case expands the spectrum of IDL-associated tumors and suggests IDLs may serve as MEC precursors.

Indexed as

Carcinoma, MucoepidermoidNeoplasms, Multiple PrimaryParotid NeoplasmsAged, 80 and overHumansMaleTrans-ActivatorsMAML2 protein, humanTrans-ActivatorsIntercalated DuctMAML2 fusionMucoepidermoid CarcinomaPrecursor

Identifiers

PMID40138019

DOI10.1007/s12105-025-01774-2

PMCPMC11947407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.