Evidence map›Paper›PMID 40138002›Full record

ArticleJournal of materials science. Materials in medicine2025

Comparison of different graft materials on the proliferation, mineralization and mineralized tissue-related gene expressions of cementoblasts.

E Elif Mutafcilar Velioğlu, S Buket Bozkurt, Werner Götz, Sema S Hakki

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

E Elif Mutafcilar VelioğluFaculty of Dentistry, Department of Periodontology, Selcuk University, Konya, Turkey. mutafcielif@gmail.com.ORCID http://orcid.org/0000-0003-1882-553X
S Buket BozkurtFaculty of Medicine, Department of Biochemistry, Niğde Ömer Halisdemir University, Niğde, Turkey.
Werner GötzFaculty of Dentistry, Department of Orthodontics, Oral Biology Lab, Bonn University, Bonn, Germany.
Sema S HakkiFaculty of Dentistry, Department of Periodontology, Selcuk University, Konya, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cementoblasts and formation of new cementum are crucial for periodontal regeneration. The aim of this study is to investigate the effect of different graft materials on cementoblast's proliferation, mineralization and mineralized tissue-related gene expressions in-vitro. Immortalized mouse cementoblasts (OCCM-30) were treated with the media containing released components of graft materials (100 mg/ml ratio; waited in 5% FBS containing media for 3 days). Proliferation of the cells was evaluated using a real-time cell analyzer for 170 h and wound healing assay was performed to determine the migration of OCCM-30 cells. Total RNA was isolated on days 3 and 6, and biomineralization of the cementoblasts was assessed using von Kossa staining. mRNA expressions of bone sialoprotein (BSP), osteocalcin (OCN), collagen type I (COL-I), runt-related transcription factor2 (Runx2), and alkaline phosphatase (ALP) genes were examined using quantitative RT-PCR. While there was no significant difference at 72 h, all test groups showed significant reduction of cementoblast's proliferation at 96

Indexed as

Calcification, PhysiologicDental CementumAlkaline PhosphataseAnimalsCell LineCell MovementCell ProliferationCollagen Type ICore Binding Factor Alpha 1 SubunitGene ExpressionGene Expression RegulationIntegrin-Binding SialoproteinMiceMineralsOsteocalcinAlkaline PhosphataseBio-OssCollagen Type ICore Binding Factor Alpha 1 SubunitIntegrin-Binding SialoproteinMineralsOsteocalcinBone graft materialsCementoblastsGene expressionMigrationMineralizationProliferation

Identifiers

PMID40138002
PMCPMC11947009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.