Evidence map›Paper›PMID 40138000›Full record

ArticleMetabolic brain disease2025

Artesunate alleviated hippocampal neuron pyroptosis by down-regulating NLRP3 in rats with cerebral small vessel disease.

Xiaokun Wang, Hequan Zhong, Xiangyu Kong, Hongqiao Wei, Bing Li

Abstract read
In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaokun Wang *Research Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 201508, China.ORCID 0000-0003-0402-9452
Hequan Zhong *Research Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 201508, China.ORCID 0000-0002-6624-5911
Xiangyu KongResearch Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 201508, China.ORCID 0000-0003-0189-255X
Hongqiao WeiSchool of Basic Medical Sciences, Guangxi Medical University, Nanning, 530022, China. weihongqiao@gxmu.edu.cn.ORCID 0009-0002-0309-0390
Bing LiResearch Center for Clinical Medicine, Jinshan Hospital Affiliated to Fudan University, Shanghai, 201508, China. libingbm@163.com.ORCID 0000-0001-5709-9396

Funding

Guangxi First-class Discipline Project for Basic medicine Sciences GXFCDP-BMS-2018
6 · The paper itself

Abstract

Our study aims to investigate the potential of artesunate (ART) in improving learning and memory function by down-regulating NLRP3 and consequently affecting pyroptosis levels in the brains of rats with cerebral small vessel disease (CSVD). Initially, Sprague-Dawley (SD) rats were randomly assigned to five groups: the solvent sham operation group, solvent model group, low-dose ART (ART

Indexed as

ArtesunateCerebral Small Vessel DiseasesHippocampusNeuronsNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAnimalsDown-RegulationMaleRatsRats, Sprague-DawleyArtesunateNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratArtesunateCerebral small vessel diseaseNLRP3Pyroptosis

Identifiers

PMID40138000
PMCPMC11947036

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.