ArticleEuropean journal of nuclear medicine and molecular imaging2025
Age-related changes of human brain metabolism.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The Impact of Estradiol Dynamics During the Menopause Transition on Depression Risk: A Narrative Review of Estradiol's Neurobiological Mechanisms.Biological psychiatry · 2026Review
- Generation of an Age-Dependent and HarmonizedHuman brain mapping · 2026Article
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Authors and funding
21 authors.
Funding
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Abstract
purposeGlucose is the primary source of human brain energy, and is closely related to brain function. This study aims to evaluate in vivo glucose metabolic changes using
methodsIn this retrospective analysis, a total of 3,291 healthy adults (aged 18 to 89 years, 1816 males) who underwent
resultsAge-related, gender-specific patterns of glucose metabolic changes are revealed, especially in the frontal, occipital, temporal and parietal lobes. A significantly decrease in metabolism is observed in males aged 45 to 70 compared to females. Metabolic aging trajectories and centile scores demonstrate a gradual decline across the total cortical, subcortical and most brain regions. Additionally, brain regions with maximum values (not at age 18), extreme age points, and their corresponding ages were identified. Specifically, only 12 brain regions exhibited values higher than those at age 18, and only 8 regions displayed extreme points throughout the aging process.
conclusionIn summary, our large population study identifies a distinct pattern of brain glucose metabolism during aging that varies between men and women, with two critical age periods based on gender: 45-49, and 70-75. We establish benchmark trajectories for various brain regions, which could serve as references in future aging studies of healthy populations. The aging peaks, including maximum and extreme points, revealed in this study may provide insight into the molecular transformations associated with aging and the development of age-related conditions. SIGNIFICANCE STATEMENT: A number of brain aging changes throughout the lifespan have been well documented, such as reductions in cerebral blood flow, cortical thickness, synaptic density, and neural activity. However, the spatiotemporal patterns of brain functional changes during normal aging remain poorly understood. In this study, we utilized the largest cohort of healthy individuals' FDG brain images to date. For the first time, we combined qualitative and quantitative metabolic aging analyses, and applied brain chart modeling to
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