Evidence map›Paper›PMID 40137942›Full record

ArticleThe Journal of membrane biology2025

Cholesterol Concentration in Cell Membranes and its Impact on Receptor-Ligand Interaction: A Computational Study of ATP-Sensitive Potassium Channels and ATP Binding.

Cesar Millan-Pacheco, Iris N Serratos, Gerardo J Félix-Martínez, Gerardo Blancas-Flores, Alejandra Osorno, Rafael Godínez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of membrane biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cesar Millan-PachecoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Morelos. Av. Universidad No. 1001, Colonia Chamilpa, 62209, Morelos, México.
Iris N SerratosDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina. Iztapalapa, C. P. 09340, Ciudad de Mexico, México. insa@xanum.uam.mx.
Gerardo J Félix-MartínezDepartamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina. Iztapalapa, C. P. 09340, Ciudad de Mexico, México.
Gerardo Blancas-FloresDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, C. P. 09340, Ciudad de Mexico, México.
Alejandra OsornoDepartamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina. Iztapalapa, C. P. 09340, Ciudad de Mexico, México.
Rafael GodínezDepartamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina. Iztapalapa, C. P. 09340, Ciudad de Mexico, México. gfjr@xanum.uam.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work describes a computer study that looks at how different amounts of cholesterol (0%, 25%, and 50%) in cell membranes change the relationship between ATP and the K

Indexed as

Adenosine TriphosphateCell MembraneCholesterolKATP ChannelsBinding SitesComputer SimulationHumansInsulin-Secreting CellsLigandsMolecular Dynamics SimulationProtein BindingAdenosine TriphosphateCholesterolKATP ChannelsLigandsAdenosine triphosphate (ATP)ATP-dependent potassium channels (KATP)Cholesterol percentageComputational approachesMolecular recognitionPancreatic beta-cells

Identifiers

PMID40137942
PMCPMC12081584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.