Evidence map›Paper›PMID 40137932›Full record

ArticleVision (Basel, Switzerland)2025

Characterizing the Preferred Retinal Locus and Fixation Stability in Diabetic Macular Ischemia: A One-Year Study.

Alicia Lim, Wei-Shan Tsai, Sridevi Thottarath, Sarega Gurudas, Taffeta Ching Ning Yamaguchi, Elizabeth Pearce, Sobha Sivaprasad

Abstract read
In one paragraph

Article in Vision (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alicia LimBarts and the London School of Medicine and Dentistry, London E1 2AD, UK.ORCID 0000-0001-8454-4790
Wei-Shan TsaiMoorfields Clinical Research Facility, NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.ORCID 0000-0001-5945-9316
Sridevi ThottarathMoorfields Clinical Research Facility, NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.
Sarega GurudasMoorfields Clinical Research Facility, NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.
Taffeta Ching Ning YamaguchiBoehringer Ingelheim, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany.
Elizabeth PearceInstitute of Ophthalmology, University College London, London EC1V 9EL, UK.
Sobha SivaprasadMoorfields Clinical Research Facility, NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London EC1V 2PD, UK.ORCID 0000-0001-8952-0659

Funding

Boehringer Ingelheim Foundation SIVS1048
6 · The paper itself

Abstract

Eyes with maculopathy usually have poor fixation stability (FS) and develop a new preferred retinal locus (PRL). The exact FS and PRL have never been studied in diabetic macular ischemia (DMI). In this one-year observational study, we recruited 79 patients (145 eyes) with evidence of DMI on optical coherence tomography angiography (OCTA). Microperimetry (MP) was performed at baseline and 52 weeks. Overall, DMI eyes demonstrated relatively stable FS without evolving into eccentric fixation over one year. When comparing the better-seeing eye (BSE) with the worse-seeing eye (WSE) in eyes with bilateral DMI, the latter presented with a larger bivariate contour ellipse area (BCEA) initially but gradually aligned with the one in the BSE at the end of the study. Conversely, the foveolar retinal sensitivity (RS) worsened significantly alongside the extension of disorganization of the retinal inner layers (DRIL) in the WSE at one year despite the best-corrected visual acuity (BCVA) being maintained. This suggests that foveolar RS might reflect the start of DMI deterioration more sensitively than BCVA.

Indexed as

bivariate contour ellipse areadiabetic macular ischemiadiabetic retinopathyfixation stabilitymicroperimetryoptical coherence tomographyoptical coherence tomography angiographypreferred retinal locusretinal sensitivityvisual acuity

Identifiers

PMID40137932
PMCPMC11945794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.