Evidence map›Paper›PMID 40137884›Full record

ArticleToxins2025

Structural and Energetic Evidence Supports the Non-Covalent Phosphate Cyclization by the Class II Phospholipase D from

Carolina Gismene, José Fernando Ruggiero Bachega, Daniel Z Doherty, Silvio Sanches Veiga, Raghuvir K Arni, Jorge Enrique Hernández González

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Spider venom phospholipase D toxin structure: Interfacial binding site, mechanism, activation, and head group preference.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina GismeneBiological Structures Group, Multiuser Center for Biomolecular Innovation (CMIB), São Paulo State University-UNESP, São José do Rio Preto CEP 15054-000, SP, Brazil.
José Fernando Ruggiero BachegaGraduate Program in Molecular and Cellular Biology, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre CEP 90050-170, RS, Brazil.
Daniel Z DohertyBiological Structures Group, Multiuser Center for Biomolecular Innovation (CMIB), São Paulo State University-UNESP, São José do Rio Preto CEP 15054-000, SP, Brazil.
Silvio Sanches VeigaDepartment of Cell Biology, Federal University of Paraná (UFPR), Curitiba CEP 81531-980, PR, Brazil.
Raghuvir K ArniBiological Structures Group, Multiuser Center for Biomolecular Innovation (CMIB), São Paulo State University-UNESP, São José do Rio Preto CEP 15054-000, SP, Brazil.ORCID 0000-0003-2460-1145
Jorge Enrique Hernández GonzálezBiological Structures Group, Multiuser Center for Biomolecular Innovation (CMIB), São Paulo State University-UNESP, São José do Rio Preto CEP 15054-000, SP, Brazil.ORCID 0000-0002-4770-8677

Funding

Brazilian Council for Scientific and Technological Development (CNPq) 309940/2019-2Brazilian Council for Scientific and Technological Development (CNPq) 401415/2023-6Sao Paulo Research Foundation (FAPESP) 2020/08615-8Sao Paulo Research Foundation (FAPESP) 2024/00876-8Sao Paulo Research Foundation (FAPESP) 2024/01956-5Sao Paulo Research Foundation (FAPESP) 2024/16184-8
6 · The paper itself

Abstract

Phospholipase D (PLD) enzymes from

Indexed as

PhosphatesPhospholipase DSpidersSpider VenomsAnimalsCyclizationMolecular Dynamics SimulationPhosphoric Diester Hydrolasesloxosceles venomPhosphatesPhospholipase DPhosphoric Diester HydrolasesSpider Venomscatalytic mechanismcrystal structurecyclic phosphateLoxoscelesphospholipase Dspider venom

Identifiers

PMID40137884
PMCPMC11945750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.