Evidence map›Paper›PMID 40137880›Full record

ReviewToxins2025

The Elias University Hospital Approach: A Visual Guide to Ultrasound-Guided Botulinum Toxin Injection in Spasticity: Part I-Distal Upper Limb Muscles.

Marius Nicolae Popescu, Claudiu Căpeț, Cristina Beiu, Mihai Berteanu

Abstract readReview
In one paragraph

Review in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marius Nicolae PopescuDepartment of Physical and Rehabilitation Medicine-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0002-9043-7585
Claudiu CăpețClinic of Physical and Rehabilitation Medicine-Elias Emergency University Hospital, 011461 Bucharest, Romania.ORCID 0009-0009-0891-4775
Cristina BeiuDepartment of Oncologic Dermatology-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0003-4632-576X
Mihai BerteanuDepartment of Physical and Rehabilitation Medicine-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.ORCID 0000-0001-9379-4580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-stroke spasticity significantly impairs upper limb function and quality of life. Ultrasound-guided botulinum toxin-A (BoNT-A) injections have become a cornerstone of management, enhancing precision and safety. This paper offers a comprehensive guide for clinicians on ultrasound-guided BoNT-A injections for distal upper limb muscles. Each muscle is detailed in terms of its role in spasticity management, ultrasound identification with key anatomical landmarks, clinical relevance, and injection strategies. Motor points, traditionally identified through anatomical studies or electromyography (EMG), are precisely localized using a musculoskeletal ultrasound by targeting the point of maximum muscle thickness, often corresponding to the motor point. The authors present their clinical method, developed at Elias University Hospital (EUH), to refine BoNT-A injection practices. This approach enhances efficacy, reduces dosage requirements, and improves patient outcomes. The paper also explores unique ultrasound characteristics of spastic muscles, such as their relationship with peripheral nerves, adjacent vascular and muscular structures, and intra- and intermuscular fascia, to guide clinicians in targeting functional muscle tissue. This guide is illustrated with representative ultrasound images and clinical diagrams and provides practical insights into anatomical relationships and injection techniques. Part I focuses on distal upper limb muscles, with Part II addressing proximal upper limb muscles.

Indexed as

Botulinum Toxins, Type AMuscle, SkeletalMuscle SpasticityNeuromuscular AgentsUltrasonography, InterventionalUpper ExtremityHospitals, UniversityHumansInjections, IntramuscularBotulinum Toxins, Type ANeuromuscular Agentsbotulinum toxin-A injectionsdistal upper limb musclesmusculoskeletal ultrasoundpost-stroke spasticityultrasound-guided therapy

Identifiers

PMID40137880
PMCPMC11945674

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.