Evidence map›Paper›PMID 40137857›Full record

ArticleMolecular biology of the cell2025

Aβ impairs the LTP-related movement of endogenous CaMKII but not of exogenous GFP-CaMKII.

Carolyn Nicole Brown, Fan-Yi Chao, Daphne Quang, Nicole L Rumian, Mason S Kleinjan, Steven J Coultrap, K Ulrich Bayer

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Degradation of CaMKII is stimulated by its active conformation.The Journal of biological chemistry · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carolyn Nicole BrownDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Fan-Yi ChaoDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Daphne QuangDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Nicole L RumianDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Mason S KleinjanDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
Steven J CoultrapDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.
K Ulrich BayerDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045.

Funding

University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
CaMKII substrate-selection in opposing forms of synaptic plasticityR01NS081248 · NINDS · UNIVERSITY OF COLORADO DENVER · PI K. Ulrich Bayer · 2013 to 2026
$4.9M
CaMKII nitrosylation in the age-related decline of synaptic plasticityR01AG067713 · NIA · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH · 2020 to 2024
$2.7M
CaMKII in global cerebral ischemiaR01NS080851 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2013 to 2017
$2.1M
CaMKII in global cerebral ischemia: mechanisms and therapeutic interventionR01NS118786 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2021 to 2025
$1.9M
Molecular computation by the CaMKII holoenzymeF31NS129254 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BROWN, CAROLYN NICOLE · 2022 to 2024
$112k
CaMKII hypo-nitrosylatlon In age-related decline of synaptic plasticity and cognitionF31AG069458 · NIA · UNIVERSITY OF COLORADO DENVER · PI RUMIAN, NICOLE · 2021 to 2022
$72k
NIA NIH HHS F31 AG069458NIA NIH HHS R01 AG067713NIA NIH HHS T32 AG000279NIGMS NIH HHS T32 GM007635NINDS NIH HHS F31 NS129254NINDS NIH HHS R01 NS080851NINDS NIH HHS R01 NS081248NINDS NIH HHS R01 NS118786
6 · The paper itself

Abstract

Amyloid β (Aβ) inhibits hippocampal long-term potentiation (LTP; a form of synaptic plasticity thought to underly learning and memory) by inhibiting the stimulation-induced synaptic accumulation of the Ca

Indexed as

Amyloid beta-PeptidesCalcium-Calmodulin-Dependent Protein Kinase Type 2Long-Term PotentiationAnimalsGreen Fluorescent ProteinsHippocampusHumansNeuronal PlasticityRatsAmyloid beta-PeptidesCalcium-Calmodulin-Dependent Protein Kinase Type 2Green Fluorescent Proteins

Identifiers

PMID40137857
PMCPMC12086577

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.