Expanded Gram-Negative Activity of Marinopyrrole A.

Clare F Euteneuer, Brianna N Davis, LeeAnna M Lui, Andrew J Neville, Paul H Davis

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Broad-Spectrum Anti-Infective Activity of Natural Compounds Pyrrolomycins, Marinopyrroles, and Their Analogs.Pathogens (Basel, Switzerland) · 2026
Review
Cancer Cell Cytotoxicity of Marinopyrroles, Pyrrolomycins, and Their Derivatives.Marine drugs · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clare F EuteneuerDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0009-0002-8193-9732

Brianna N DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0009-0002-3230-4378

LeeAnna M LuiDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0000-0002-7938-9252

Andrew J NevilleDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0000-0001-6237-9640

Paul H DavisDepartment of Biology, University of Nebraska at Omaha, Omaha, NE 68182, USA.ORCID 0000-0002-0526-3841

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Heather Colleen Jensen-Smith · 2012 to 2026

$59.2M

NIGMS NIH HHS P20 GM103427NIH HHS 5P20GM103427-23S22

6 · The paper itself

Abstract

The rise of bacterial infections is a global health issue that calls for the development and availability of additional antimicrobial agents. Known for its in vitro effects on Gram-positive organisms, the drug-like small molecule marinopyrrole A was re-examined for the potential of broader efficacy against a wider array of microbes. We uncovered selective efficacy against an important subset of Gram-negative bacteria from three genera:

Indexed as

Anti-Bacterial AgentsGram-Negative BacteriaPyrrolesLipopolysaccharidesMicrobial Sensitivity TestsAnti-Bacterial AgentsLipopolysaccharidesPyrrolesantibacterialbacterial infectionsmarinopyrrole Asusceptibility screening

Identifiers

PMID40137776

DOI10.3390/pathogens14030290

PMCPMC11946689

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.