Evidence map›Paper›PMID 40137771›Full record

ArticlePathogens (Basel, Switzerland)2025

Human Retinal Organoid Model of Ocular Toxoplasmosis.

Liam M Ashander, Grace E Lidgerwood, Amanda L Lumsden, João M Furtado, Alice Pébay, Justine R Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Liam M AshanderFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-3808-9763
Grace E LidgerwoodDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-1774-5944
Amanda L LumsdenFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-0214-6498
João M FurtadoDivision of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, São Paulo, Brazil.ORCID 0000-0003-2490-5747
Alice PébayDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
Justine R SmithFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.ORCID 0000-0002-4756-5493

Funding

Dame Kate Campbell FellowshipDHB Foundation N/ANational Health and Medical Research Council Senior Research Fellowship (1154389)
6 · The paper itself

Abstract

The health burden of ocular toxoplasmosis is substantial, and there is an unmet need for safe and curative anti-microbial drugs. One major barrier to research on new therapeutics is the lack of in vitro human-based models beyond two-dimensional cultured cells and tissue explants. We aimed to address this research gap by establishing a human retinal organoid model of ocular toxoplasmosis. Retinal organoids, generated from human induced pluripotent stem cells and grown to two stages of organization, were incubated with a suspension of live or heat-killed GT-1 strain

Indexed as

OrganoidsRetinaToxoplasmaToxoplasmosis, OcularCytokinesHumansInduced Pluripotent Stem CellsCytokinesocular toxoplasmosisretinitisuveitis

Identifiers

PMID40137771
PMCPMC11945118

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.