Metronidazole Activation by a Deeply Entangled Dimeric Malic Enzyme in

Arindam Chakrabarty, Debajyoti Dutta, Mithu Baidya, Anirudha Dutta, Amit Kumar Das, Sudip K Ghosh

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arindam ChakrabartyDepartment of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

Debajyoti DuttaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala 147004, India.ORCID 0000-0003-0403-2192

Mithu BaidyaDepartment of Biosciences and Bioengineering, Indian Institute of Technology Jammu, Jammu and Kashmir 181221, India.

Anirudha DuttaDepartment of Biological Sciences, Adamas University, Kolkata 700126, India.

Amit Kumar DasDepartment of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.ORCID 0000-0001-9703-1898

Sudip K GhoshDepartment of Bioscience and Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.ORCID 0000-0002-6285-1519

Funding

Indian Institute of Technology Kharagpur Institute internal fundIndian Institute of Technology Kharagpur, India Institute internal fund.

6 · The paper itself

Abstract

Metronidazole is the preferred drug for treating amoebiasis caused by

Indexed as

Antiprotozoal AgentsEntamoeba histolyticaMalate DehydrogenaseMetronidazoleEnzyme ActivationHumansModels, MolecularProtein MultimerizationAntiprotozoal AgentsMalate Dehydrogenasemalate dehydrogenase (decarboxylating)Metronidazolecrystal structureEntamoeba histolyticaentangled proteinknotmetronidazoleprotozoa

Identifiers

PMID40137762

DOI10.3390/pathogens14030277

PMCPMC11944484

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.