Evidence map›Paper›PMID 40137706›Full record

ArticlePathogens (Basel, Switzerland)2025

A Combination of Flavonoids Suppresses Cell Proliferation and the E6 Oncogenic Pathway in Human Papillomavirus-Transformed Cells.

Federico De Marco, Fabio Altieri, Stefano Giuliani, Italia Falcone, Susanna Falcucci, Mariassunta Tedesco, Roberto Becelli

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prunin: An Emerging Anticancer Flavonoid.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Federico De MarcoIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-1173-2843
Fabio AltieriMedicine and Pharmacy Faculty, Sapienza Rome University, Ple Aldo Moro 5, 00185 Rome, Italy.ORCID 0000-0002-6546-2738
Stefano GiulianiIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0009-0008-9905-7870
Italia FalconeIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0003-2796-0792
Susanna FalcucciIRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.ORCID 0000-0002-3058-4647
Mariassunta TedescoMedicine and Pharmacy Faculty, Sapienza Rome University, Ple Aldo Moro 5, 00185 Rome, Italy.
Roberto BecelliMedicine and Psychology Faculty, Sapienza Rome University, Via di Grottarossa 1035, 00189 Rome, Italy.

Funding

NP1 Srl Roma - Italy NP1 Srl Roma - Italy. No numerical grant ID
6 · The paper itself

Abstract

Despite the availability of excellent HPV-specific vaccines, HPV-related conditions and, notably, their related neoplastic diseases are expected to impact human health for many years to come. Polyphenols and flavonoids are a large class of natural products, credited with a wide range of pharmacological properties including antineoplastic activity. However, the currently available data depict a rather heterogeneous and sometimes contradictory landscape, and no univocal conclusions can be drawn. To shed light on such a controversial issue, a restricted list of promising polyphenols were evaluated for their antineoplastic activity on HPV-transformed cells. Among them, Kaempferol, Galangin, and Luteolin proved to have distinct anti-clonal activity with ID

Indexed as

Antineoplastic AgentsCell ProliferationCell Transformation, ViralFlavonoidsOncogene Proteins, ViralPapillomaviridaeHuman Papillomavirus VirusesHumansKaempferolsLuteolinPapillomavirus InfectionsAntineoplastic AgentsFlavonoidsgalanginkaempferolKaempferolsLuteolinOncogene Proteins, Viralanti-clonal effectapigeninchrysinE6flavonoidsgalanginkaempferolluteolinquercetin

Identifiers

PMID40137706
PMCPMC11945172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.