ArticleNanomaterials (Basel, Switzerland)2025
Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.Particle and fibre toxicology · 2025Pooled it
- Polystyrene Nanoplastics Increase Macrophage Bactericidal Activity Through a Mechanism Involving Reactive Oxygen Species and Itaconate.Nanomaterials (Basel, Switzerland) · 2026Article
- Comparative Metabolomic Approaches to Nanoplastic Toxicity in Mammalian and Aquatic Systems.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
A critical knowledge gap currently exists regarding the potential risks of exposure to nanoplastics (NPs), particularly early in life during key stages of growth and development. Globally abundant plastics, polyamide (nylon) and polystyrene (PS), exist in various products and have been detected in food and beverages as small-scale plastics. In this study, we evaluated how early-life exposure to NPs affects key biological metrics in rat pups. Male and female animals received an oral dose (20 mg/kg/day) of nylon-11 NPs (114 ± 2 nm) or PS NPs (85 ± 1 nm) between postnatal day (PND) 7 and 10. The results showed slight differences in the ratio of liver weight to body weight for male rat pups exposed to PS NPs. Cardiac performance and levels of neurotransmitters and related metabolites in brain tissue showed no differences between animals exposed to NPs and controls. The endogenous metabolite profile in plasma was altered by oral administration of NPs, suggesting perturbation of metabolic pathways involved in amino acid and lipid metabolism. This study explored the biological impacts of oral NP exposure early in life, supporting the need for continued investigations into the potential health effects from exposure to NPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.