ArticleNanomaterials (Basel, Switzerland)2025
Investigating Simulated Cellular Interactions on Nanostructured Surfaces with Antibacterial Properties: Insights from Force Curve Simulations.
Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigates the simulation of interactions between cells and antibacterial nanostructured surfaces. Understanding the physical interaction forces between cells and nanostructured surfaces is crucial for developing antibacterial materials, yet existing physical models are limited. Force simulation studies can simplify analysis by focusing on mechanical interactions while disregarding factors such as bacterial deformation and complex biochemical signals. To simulate these interactions, Atomic Force Microscopy (AFM) was employed to generate force curves, allowing precise monitoring of the interaction between a 5 µm spherical cantilever tip and titanium alloy (Ti6Al4V) surfaces. AFM uniquely enables customized approaches and retraction cycles, providing detailed insights into attractive-repulsive forces across different surface morphologies. Two nanostructured surfaces, created via hydrothermal etching using KOH and NaOH, were compared to a Ti6Al4V control surface. Results demonstrated significant changes in nanomechanical properties due to surface chemistry and morphology. The Ti6Al4V control surface exhibited a 44 ± 5 N/m stiffness, which decreased to 20 ± 3 N/m on KOH-etched nanostructured (NS) surfaces and 29 ± 4 N/m on NaOH-etched NS surfaces. Additionally, surface energy decreased by magnitude on nanostructured surfaces compared to the control. The nature of interaction forces also varied: short-range forces were predominant on KOH-etched surfaces, while NaOH-etched surfaces exhibited stronger long-range forces. These findings provide valuable insights into how nanostructure patterning influences cell-like interactions, offering potential applications in antibacterial surface design. By tailoring nanomechanical properties through specific etching techniques, biomaterial performance can be optimized for clinical applications, enhancing antibacterial efficacy and reducing microbial adhesion.
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