Evidence map›Paper›PMID 40137575›Full record

ArticleTomography (Ann Arbor, Mich.)2025

Ground-Glass Opacities in the Access Route and Biopsy in Highly Perfused Dependent Areas of the Lungs as Risk Factors for Pulmonary Hemorrhage During CT-Guided Lung Biopsy: A Retrospective Study.

Michael P Brönnimann, Leonie Manser, Andreas Christe, Johannes T Heverhagen, Bernhard Gebauer, Timo A Auer, Dirk Schnapauff, Federico Collettini, Christophe Schroeder, Patrick Dorn and 3 more

Abstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michael P BrönnimannDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.ORCID 0000-0003-0552-4850
Leonie ManserDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.
Andreas ChristeDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.ORCID 0000-0002-2355-2591
Johannes T HeverhagenDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.
Bernhard GebauerDepartment of Radiology, Charité-Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-9948-7220
Timo A AuerDepartment of Radiology, Charité-Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0002-5763-689X
Dirk SchnapauffDepartment of Radiology, Charité-Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany.
Federico CollettiniDepartment of Radiology, Charité-Universitätsmedizin Augustenburger Platz 1, 13353 Berlin, Germany.ORCID 0000-0001-5378-461X
Christophe SchroederDepartment of Radiology, Centre Hospitalier du Nord, 120 Av. Lucien Salentiny, Ettelbruck, 9080 Luxembourg, Luxembourg.
Patrick DornDepartment of Thoracic Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 4, 3010 Bern, Switzerland.ORCID 0000-0002-7203-3122
Tobias GassenmaierDepartment of Radiology and Nuclear Medicine, Cantonal Hospital Lucerne, University of Lucerne, 6000 Lucerne, Switzerland.ORCID 0000-0002-1089-2036
Lukas EbnerDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.
Adrian T HuberDepartment of Diagnostic, Interventional and Paediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Rosenbühlgasse 27, 3010 Bern, Switzerland.ORCID 0000-0001-6146-8238

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe risk of hemorrhage during CT-guided lung biopsy has not been systematically studied in cases where ground-glass opacities (GGO) are present in the access route or when biopsies are performed in highly perfused, dependent lung areas. While patient positioning has been studied for pneumothorax prevention, its role in minimizing hemorrhage risk remains unexplored. This study aimed to determine whether GGOs in the access route and biopsies in dependent lung areas are risk factors for pulmonary hemorrhage during CT-guided lung biopsy.

methodsA retrospective analysis was conducted on 115 CT-guided lung biopsies performed at a single center (2020-2023). Patients were categorized based on post-interventional hemorrhage exceeding 2 cm (Grade 2 or higher). We evaluated the presence of GGOs in the access route and biopsy location (dependent vs. non-dependent areas) using chi square, Fisher's exact, and Mann-Whitney U tests. Univariate and multivariate logistic regression analyses were conducted to evaluate risk factors for pulmonary hemorrhage.

resultsPulmonary hemorrhage beyond 2 cm occurred in 30 of 115 patients (26%). GGOs in the access route were identified in 67% of these cases (

conclusionsGGOs in the access route and dependent lung area biopsies are independent risk factors for hemorrhage during CT-guided lung biopsy.

Indexed as

HemorrhageImage-Guided BiopsyLungLung DiseasesTomography, X-Ray ComputedAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk Factorsbiopsyhemorrhageimage-guided biopsyradiography interventionalrisk factorstomography

Identifiers

PMID40137575
PMCPMC11945665

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.