Evidence map›Paper›PMID 40137521›Full record

ArticleToxics2025

Preliminary Insights into the Cyto/Genoprotective Properties of Propolis and Its Constituent Galangin In Vitro.

Mateo Jakac, Irena Brčić Karačonji, Andreja Jurič, Dražen Lušić, Danijel Milinčić, Aleksandra Dramićanin, Mirjana Pešić, Nediljko Landeka, Nevenka Kopjar

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mateo JakacDepartment of Epidemiology, Teaching Institute of Public Health of Istria County, 52000 Pula, Croatia.ORCID 0009-0004-5357-4945
Irena Brčić KaračonjiDivision of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.ORCID 0000-0002-1151-8839
Andreja JuričDivision of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.ORCID 0000-0002-9279-5159
Dražen LušićDepartment of Basic Medical Sciences, Faculty of Health Studies, University of Rijeka, 51000 Rijeka, Croatia.ORCID 0000-0002-1636-6512
Danijel MilinčićDepartment of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, 11080 Belgrade, Serbia.
Aleksandra DramićaninDepartment of Analytical Chemistry, Faculty of Chemistry, University of Belgrade, 11158 Belgrade, Serbia.ORCID 0000-0001-9754-858X
Mirjana PešićDepartment of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, 11080 Belgrade, Serbia.ORCID 0000-0001-9779-1686
Nediljko LandekaDepartment of Epidemiology, Teaching Institute of Public Health of Istria County, 52000 Pula, Croatia.
Nevenka KopjarDivision of Toxicology, Institute for Medical Research and Occupational Health, 10000 Zagreb, Croatia.ORCID 0000-0002-3117-2847

Funding

Croatian Academy of Sciences and Arts NAHrvatska elektroprivreda d.d. NANext Generation EU 533-03-23-0006Prometheus Fund NA
6 · The paper itself

Abstract

Propolis has been well known for centuries as a natural preventive and therapeutic agent. Its numerous health benefits are mainly attributed to its high content of phenolic compounds that have a remarkable antioxidant activity. Since phenolics may exert a dual nature (pro-oxidant and antioxidant) the aim of this study was to investigate the safety profile of the ethanolic extract of propolis and the related flavonoid galangin and their ability to protect lymphocytes from irinotecan-induced cyto/genotoxicity in vitro. Isolated human peripheral blood lymphocytes were exposed for 3 h to three concentrations of propolis extract and galangin corresponding to the average daily dose of 0.25 mL of extract [propolis in 70% ethanol (3:7,

Indexed as

cytokinesis-block micronucleus cytome assaygalanginirinotecanlymphocytesphenolicspropolis

Identifiers

PMID40137521
PMCPMC11946679

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.