Evidence map›Paper›PMID 40137509›Full record

ArticleToxics2025

Spatially Resolved Metabolomics and Network Pharmacology Reveal Extract D Nephrotoxicity Mechanisms in

Haiyan Jiang, Ying Wang, Xiaoyan Duan, Shushu Guo, Xiaoyu Fan, Tianyu Zhou, Jie Li, Jiuming He, Jianbo Yang, Hongtao Jin

Abstract read
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Haiyan JiangNew Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID 0000-0001-7068-1364
Ying WangNational Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0000-0002-9659-3538
Xiaoyan DuanNew Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Shushu GuoDepartment of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.
Xiaoyu FanNew Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Tianyu ZhouCollege of Pharmacy, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China.
Jie LiNew Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID 0000-0002-0843-6349
Jiuming HeState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID 0000-0002-6545-472X
Jianbo YangNational Institutes for Food and Drug Control, Beijing 102629, China.ORCID 0000-0002-1368-5294
Hongtao JinNew Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID 0000-0002-0638-707X

Funding

Chinese Academy of Medical Science Innovation Fund for Medical Sciences 2022-I2M-2-002National Natural Science Foundation of China 81973476National Natural Science Foundation of China 82074104Research Project of Clinical Toxicology Transformation from the Chinese Society of Toxicology CST2021CT101
6 · The paper itself

Abstract

As a traditional Chinese medicine, the adverse hepatotoxicity effects of

Indexed as

mass spectrometry imagingnetwork pharmacologyPleuropterus multiflorus (Thunb.) Nakairenal toxicityspatially resolved metabolomics

Identifiers

PMID40137509
PMCPMC11946316

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.