Evidence map›Paper›PMID 40137503›Full record

ArticleToxics2025

Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole.

Cristian Falero, Wilfredo Huanca, Luis Barrios-Arpi, Boris Lira-Mejía, Olger Ramos-Coaguila, Edith Torres, Eva Ramos, Alejandro Romero, Mariella Ramos-Gonzalez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cristian FaleroZootecnia an Animal Production Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.
Wilfredo HuancaReproduction Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.ORCID 0000-0002-7601-0067
Luis Barrios-ArpiAnimal Physiology Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.ORCID 0000-0002-5166-4136
Boris Lira-MejíaAnimal Physiology Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.ORCID 0000-0003-1497-3068
Olger Ramos-CoaguilaZootecnia an Animal Production Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.ORCID 0000-0002-9160-2562
Edith TorresReproduction Laboratory, School of Veterinary and Zootecnic Medicine, Jorge Basadre Grohmann University, Tacna 23001, Peru.ORCID 0000-0002-9222-1657
Eva RamosDepartment of Pharmacology and Toxicology, Faculty of Veterinary, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-5791-0687
Alejandro RomeroDepartment of Pharmacology and Toxicology, Faculty of Veterinary, Complutense University of Madrid, 28040 Madrid, Spain.ORCID 0000-0001-5483-4973
Mariella Ramos-GonzalezZootecnia an Animal Production Laboratory, Faculty of Veterinary Medicine, Major National University of San Marcos, Lima 15021, Peru.ORCID 0000-0001-9990-4074

Funding

National University of San Marcos PCONFIGI-A24080071
6 · The paper itself

Abstract

Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In the present study, the cytotoxic effect of the triazole ipconazole was evaluated in porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase and SOD enzyme activity, and caused alterations in the molecular mRNA expression of structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 and CLGN) related to fertility in males, as well as the overexpression of BAX (cell death) and ROMO1 (oxidative stress) mRNA. Our results indicate that the fungicide triazole is involved in cellular, enzymatic and molecular alteration of porcine and ram spermatozoa, and is possibly a factor in the development of infertility in male mammals.

Indexed as

ipconazoleoxidative stressspermiotoxicitystructural biomarkers

Identifiers

PMID40137503
PMCPMC11945538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.