Evidence map›Paper›PMID 40137359›Full record

ReviewJournal of functional biomaterials2025

Polymer-Based Scaffolds as an Implantable Material in Regenerative Dentistry: A Review.

Lubos Lesko, Petra Jungova, Martina Culenova, Andrej Thurzo, Lubos Danisovic

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lubos LeskoInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.
Petra JungovaDepartment of Orthodontics, Regenerative and Forensic Dentistry, Faculty of Medicine, Comenius University in Bratislava, Dvořákovo nábrežie 4, 811 02 Bratislava, Slovakia.ORCID 0009-0001-4599-0461
Martina CulenovaInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.ORCID 0009-0005-3484-0002
Andrej ThurzoDepartment of Orthodontics, Regenerative and Forensic Dentistry, Faculty of Medicine, Comenius University in Bratislava, Dvořákovo nábrežie 4, 811 02 Bratislava, Slovakia.ORCID 0000-0002-7810-5721
Lubos DanisovicInstitute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.ORCID 0000-0002-5074-9621

Funding

Operational Programme Integrated Infrastructure funded by the European Regional Develop-ment Fund 313011V358
6 · The paper itself

Abstract

Polymer-based scaffolds have emerged as transformative materials in regenerative dentistry, enabling the restoration and replacement of dental tissues through tissue engineering approaches. These scaffolds, derived from natural and synthetic polymers, mimic the extracellular matrix to promote cellular attachment, proliferation, and differentiation. Natural polymers such as collagen, chitosan, and alginate offer biocompatibility and bioactivity, while synthetic alternatives like polylactic acid (PLA) and polycaprolactone (PCL) provide tunable mechanical properties and degradation rates. Recent advancements highlight the integration of bioactive molecules and nanotechnology to enhance the regenerative potential of these materials. Furthermore, developing hybrid scaffolds combining natural and synthetic polymers addresses biocompatibility and mechanical strength challenges, paving the way for patient-specific treatments. Innovations in 3D bioprinting and stimuli-responsive biomaterials are expected to refine scaffold design further, improving therapeutic precision and clinical outcomes. This review underscores the critical role of polymer-based scaffolds in advancing regenerative dentistry, focusing on their applications, advantages, and limitations.

Indexed as

dental tissue regenerationpolymer-based scaffoldsregenerative dentistrytissue engineering

Identifiers

PMID40137359
PMCPMC11943271

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.