Evidence map›Paper›PMID 40137319›Full record

ArticleMarine drugs2025

Marine-Derived Alternariol Suppresses Inflammation by Regulating T Cell Activation and Migration.

Chenfeng Liu, Fudie Gu, Zhengbiao Zou, Fengli Wang, Dashuai Li, Jing Song, Yazhen Hong, Xuhui Wu, Xianwen Yang, Wen-Hsien Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenfeng LiuDepartment of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, China.
Fudie GuXiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.
Zhengbiao ZouHainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China.
Fengli WangDepartment of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, China.ORCID 0009-0002-2233-0732
Dashuai LiDepartment of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, China.
Jing SongState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.
Yazhen HongState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.
Xuhui WuSchool of Public Health, Xiamen University, Xiamen 361102, China.
Xianwen YangHainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China.ORCID 0000-0002-4967-0844
Wen-Hsien LiuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.ORCID 0000-0003-2500-3892
Guangming LiuXiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-8689-0504
Yu ZhouState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China.
Qingmei LiuXiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China.ORCID 0000-0002-9602-6680

Funding

Key Project of Natural Science Research of Anhui Education Department 2022AH050778the National Natural Science Foundation of China 32472334the National Natural Science Foundation of China 82202006the Science and Technology Program of Xiamen City 2023CXY0307the Xiamen Marine Development Program of China 22GYY007HJ07
6 · The paper itself

Abstract

T cells play pivotal roles in inflammation's initiation and progression. Exploring natural compounds that regulate T cell function is crucial for preventing and treating inflammation. Herein, we report that Alternariol (AOH), a marine-derived secondary metabolite, exerts an anti-inflammatory activity by targeting T cell function. Using an ovalbumin (OVA)-induced OT-II CD4

Indexed as

Anti-Inflammatory AgentsInflammationLactonesLymphocyte ActivationT-LymphocytesAnimalsApoptosisAquatic OrganismsCell MovementCell ProliferationCytokinesMiceMice, Inbred C57BLOvalbuminAnti-Inflammatory AgentsCytokinesLactonesOvalbuminalternariolCD4+ T cellscell migrationinflammation cytokineslung injury

Identifiers

PMID40137319
PMCPMC11944012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.