Evidence map›Paper›PMID 40137312›Full record

ArticleMarine drugs2025

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in

Gabriel Castro-Falcón, Dulce G Guillén-Matus, Elany Barbosa Da Silva, Wentao Guo, Alicia Ross, Mateus Sá Magalhães Serafim, Thaís Helena Maciel Fernandes, Dean J Tantillo, Anthony J O'Donoghue, Paul R Jensen

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Gabriel Castro-FalcónCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 93093, USA.
Dulce G Guillén-MatusCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 93093, USA.ORCID 0000-0002-3627-6186
Elany Barbosa Da SilvaSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, CA 92093, USA.
Wentao GuoDepartment of Chemistry, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0001-8058-8323
Alicia RossDepartment of Chemistry, University of California Davis, Davis, CA 95616, USA.
Mateus Sá Magalhães SerafimSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-7505-8659
Thaís Helena Maciel FernandesSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5910-0792
Dean J TantilloDepartment of Chemistry, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-2992-8844
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences, Center for Discovery and Innovation in Parasitic Diseases, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5695-0409
Paul R JensenCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 93093, USA.

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS R01 GM085770NIGMS NIH HHS R01GM085770
6 · The paper itself

Abstract

Pseudopeptides are attractive agents for protease inhibition due to their structural similarities to the natural substrates of these enzymes, as well as their enhanced stability and resistance to enzymatic degradation. We report three new ketomemicin pseudopeptides (

Indexed as

ActinobacteriaMicromonosporaceaeProtease InhibitorsBiosynthetic PathwaysMultigene FamilyProtease Inhibitorsketomemicinsnatural productspseudopeptidesSalinispora

Identifiers

PMID40137312
PMCPMC11943689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.