ArticleMarine drugs2025
The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex.
Karina S Krings, Anastasia Ritchie, Laura Schmitt, Judith Hatzfeld, Gudrun Totzke, Thomas Lenz, María José Mendiburo, Björn Stork, Nicole Teusch, Peter Proksch and 3 more
Abstract read
In one paragraphArticle in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Karina S KringsInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0001-6519-1395 Anastasia RitchieInstitute of Virology, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Laura SchmittInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Judith HatzfeldInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0009-0008-7466-5431 Gudrun TotzkeInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Thomas LenzMolecular Proteomics Laboratory, Biological-Medical-Research Center (BMFZ), Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0002-4799-5549 María José MendiburoInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Björn StorkInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0002-4167-7806 Nicole TeuschInstitute of Pharmaceutical Biology and Biotechnology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0002-9030-1493 Peter ProkschInstitute of Pharmaceutical Biology and Biotechnology, Faculty of Mathematics and Natural Sciences, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Kai StühlerMolecular Proteomics Laboratory, Biological-Medical-Research Center (BMFZ), Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.
Lisa MüllerInstitute of Virology, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0002-0728-0012 Sebastian WesselborgInstitute for Molecular Medicine I, Medical Faculty and University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Universitaetsstraße 1, 40225 Duesseldorf, Germany.ORCID 0000-0002-5236-942X Funding
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 270650915/GRK 2158 (to B.S., P.P., and S.W.)
6 · The paper itselfAbstract
Polybrominated diphenyl ethers (PBDEs) are natural products with potent antimicrobial and antineoplastic activity. We have previously shown that the polybrominated diphenyl ether bromoxib (4,5,6-tribromo-2-(2',4'-dibromophenoxy) phenol), isolated from the marine sponge
Indexed as
Active Transport, Cell NucleusHalogenated Diphenyl EthersNuclear Pore Complex ProteinsPoriferaAnimalsAntineoplastic AgentsCell Line, TumorCell NucleusHumansAntineoplastic AgentsHalogenated Diphenyl EthersNuclear Pore Complex Proteinsmarine sponge-derived natural productsnuclear import and exportnuclear pore complex (NPC)nucleoporins (NUPs)polybrominated diphenyl ethers (PBDEs)
Identifiers
PMID40137294
PMCPMC11943847
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