Evidence map›Paper›PMID 40137253›Full record

ArticleJournal of fungi (Basel, Switzerland)2025

Adaptative Divergence of

Camila Botelho Miguel, Geovana Pina Vilela, Lara Mamede Almeida, Mariane Andrade Moreira, Glicélia Pereira Silva, Jamil Miguel-Neto, Melissa Carvalho Martins-de-Abreu, Ferdinando Agostinho, Javier Emilio Lazo-Chica, Mariana Santos Cardoso and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Camila Botelho MiguelMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Geovana Pina VilelaMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Lara Mamede AlmeidaMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Mariane Andrade MoreiraMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Glicélia Pereira SilvaMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Jamil Miguel-NetoMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.ORCID 0000-0002-7024-1294
Melissa Carvalho Martins-de-AbreuMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.
Ferdinando AgostinhoFaculty of Physiotherapy, University of Rio Verde, UniRv, Rio Verde 75901-970, GO, Brazil.
Javier Emilio Lazo-ChicaLaboratory of Cell Biology, Department of Structural Biology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro (UFTM), Uberaba 38061-500, MG, Brazil.ORCID 0000-0003-1950-1895
Mariana Santos CardosoMolecular and Computational Biology of Fungi Laboratory, Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.ORCID 0000-0002-4351-5835
Siomar de Castro SoaresPostgraduate Program in Tropical Medicine and Infectious Diseases, Federal University of the Triângulo Mineiro-UFTM, Uberaba 38025-180, MG, Brazil.ORCID 0000-0001-7299-3724
Aristóteles Góes-NetoMolecular and Computational Biology of Fungi Laboratory, Department of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Wellington Francisco RodriguesMultidisciplinary Laboratory of Scientific Evidence, University Center of Mineiros (Unifimes), Mineiros 75833-130, GO, Brazil.ORCID 0000-0002-3426-2186

Funding

Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00181-23National Council for Scientific and Technological Development 102630/2024-0
6 · The paper itself

Abstract

methodsAn in silico observational study was conducted with 16

resultsMolecular phenetic analysis revealed distinct clustering patterns among isolates, reflecting adaptations associated with clinical and environmental niches. Clinical isolates demonstrated enriched sulfur metabolism and glutathione pathways, likely adaptations to oxidative stress in host environments, while environmental isolates favored methane and glyoxylate pathways, suggesting adaptations for survival in carbon-rich environments.

conclusionSignificant phenetic and metabolomic distinctions between isolates reveal adaptive strategies for enhancing virulence and antifungal resistance, highlighting potential therapeutic targets.

Indexed as

antifungal resistanceclinical isolatesCryptococcus neoformansenvironmental isolatesmetabolomicsphenetic analysisvirulence adaptation

Identifiers

PMID40137253
PMCPMC11943092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.