Evidence map›Paper›PMID 40137130›Full record

ArticleMetabolites2025

Studies of

Luis S Muñoz-Carrillo, Eduardo Madrigal-Bujaidar, Sandra L Hernández-Ojeda, José A Morales-González, Eduardo O Madrigal-Santillán, Isela Álvarez-González, J Javier Espinosa-Aguirre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Luis S Muñoz-CarrilloLaboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Zacatenco, Av. Wilfrido Massieu s/n, Gustavo A. Madero, Ciudad de Mexico 07738, Mexico.ORCID 0009-0009-0500-3191
Eduardo Madrigal-BujaidarLaboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Zacatenco, Av. Wilfrido Massieu s/n, Gustavo A. Madero, Ciudad de Mexico 07738, Mexico.
Sandra L Hernández-OjedaInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Tercer Circuito Exterior s/n, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.ORCID 0000-0003-4323-394X
José A Morales-GonzálezLaboratorio de Medicina de la Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de Mexico 11340, Mexico.ORCID 0000-0002-5980-0980
Eduardo O Madrigal-SantillánLaboratorio de Medicina de la Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de Mexico 11340, Mexico.ORCID 0000-0003-2264-4598
Isela Álvarez-GonzálezLaboratorio de Genética, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Zacatenco, Av. Wilfrido Massieu s/n, Gustavo A. Madero, Ciudad de Mexico 07738, Mexico.ORCID 0000-0003-4011-9121
J Javier Espinosa-AguirreInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Tercer Circuito Exterior s/n, Ciudad Universitaria, Ciudad de Mexico 04510, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOBJECTIVES/

methodsIn the present report, we extended this evaluation by using five strains of the

resultsOur results confirmed the absence of mutagenicity in the ethanol plant extract, as well as a concentration-dependent inhibitory effect on the damage induced by benzo[a]pyrene (BaP). With respect to safrole, we also determined that the compound has no mutagenic potential and has a strong inhibitory effect on the damage induced by BaP. Docking and kinetic analysis confirmed the coupling of safrole with the active site of the CYP1A1 enzyme, leading to competitive inhibition.

conclusionsThese results suggest that the inhibitory effect on the enzyme activity is one of the possible antimutagenic mechanisms.

Indexed as

Ames testCYP1A1docking studiesmutagenicity/antimutagenicityPiper auritumsafrole

Identifiers

PMID40137130
PMCPMC11943675

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.