Evidence map›Paper›PMID 40137111›Full record

ArticleMetabolites2025

A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells.

Ebru Ece Gülşan, Farrhin Nowshad, Meredith Davis Leigh, Jimmy Walter Crott, Hyejin Park, Greg Martin, Stephen Safe, Robert S Chapkin, Arul Jayaraman, Kyongbum Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ebru Ece GülşanDepartment of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA.
Farrhin NowshadArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-0959-7005
Meredith Davis LeighJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
Jimmy Walter CrottDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
Hyejin ParkDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.
Greg MartinDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.
Stephen SafeDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-2115-3060
Robert S ChapkinDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6515-3898
Arul JayaramanArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX 77843, USA.
Kyongbum LeeDepartment of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA.ORCID 0000-0002-0699-8057

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Galen Newman · 2019 to 2026
$13.0M
Microbial flavonoid metabolites as modulators of AD markers in a 3D human neural tissue modelR01AT010282 · NCCIH · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN, JAYARAMAN, ARUL · 2018 to 2021
$1.9M
NCCIH NIH HHS R01 AT010282NIEHS NIH HHS P30 ES029067NIH HHS Grant R01 AT010282
6 · The paper itself

Abstract

Gut microbial metabolism of dietary flavonoids leads to a diverse array of bioactive products that are closely associated with human health. Combining enzyme promiscuity prediction, metabolomics, and in vitro model systems, we identified a chalcone-synthase-like bacterial polyketide synthase that can initiate the metabolism of naringenin by catalyzing the C-ring cleavage. This was validated using a mutant strain of the model organism

Indexed as

aryl hydrocarbon receptorflavonoidsgut microbiomenaringeninring cleavage

Identifiers

PMID40137111
PMCPMC11943482

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.