Evidence map›Paper›PMID 40136968›Full record

ArticleBiosensors2025

An Antimicrobial and Antifibrotic Coating for Implantable Biosensors.

Sofia Wareham-Mathiassen, Pawan Jolly, Nandhinee Radha Shanmugam, Badrinath Jagannath, Pranav Prabhala, Yunhao Zhai, Alican Ozkan, Arash Naziripour, Rohini Singh, Henrik Bengtsson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sofia Wareham-MathiassenWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.ORCID 0000-0003-2382-4240
Pawan JollyWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Nandhinee Radha ShanmugamWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.ORCID 0000-0002-8572-7801
Badrinath JagannathWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Pranav PrabhalaWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Yunhao ZhaiWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Alican OzkanWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.ORCID 0000-0002-3825-5899
Arash NaziripourWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.
Rohini SinghWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.ORCID 0000-0002-1954-5655
Henrik BengtssonNovo Nordisk A/S, 2880 Bagsværd, Denmark.
Thomas BjarnsholtCosterton Biofilm Center, Copenhagen University, 2200 Copenhagen, Denmark.ORCID 0000-0002-8003-7414
Donald E IngberWyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA.ORCID 0000-0002-4319-6520

Funding

RESEARCH TRAINING IN NEPHROLOGYT32DK007199 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLAK, MARTIN R. · 1986 to 2022
$6.0M
Danish Diabetes Academy NNF17S0031406NIDDK NIH HHS 5T32DK007199-44NIDDK NIH HHS T32 DK007199Novo Nordisk Foundation NNF17S0031406
6 · The paper itself

Abstract

Biofouling and foreign body responses have deleterious effects on the functionality and longevity of implantable biosensors, seriously impeding their implementation for long-term monitoring. Here, we describe a nanocomposite coating composed of a cross-linked lattice of bovine serum albumin and pentaamine-functionalized reduced graphene that is covalently coupled to antibody ligands for analyte detection as well as antibiotic drugs (gentamicin or ceftriaxone), which actively combats biofouling while retaining high electroconductivity and excellent electrochemical immunosensor behavior. Sensors overlaid with this coating inhibit the proliferation of

Indexed as

Biosensing TechniquesAnimalsAnti-Bacterial AgentsBiofoulingFibroblastsGraphiteHumansNanocompositesProstheses and ImplantsPseudomonas aeruginosaSerum Albumin, BovineAnti-Bacterial AgentsGraphiteSerum Albumin, Bovineantifoulingantimicrobialdiagnosticselectrochemical sensorglucometerimplantmultiplexingwearable

Identifiers

PMID40136968
PMCPMC11940466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.