Evidence map›Paper›PMID 40136960›Full record

ArticleBiosensors2025

Smartphone Biosensors for Non-Invasive Drug Monitoring in Saliva.

Atheer Awad, Lucía Rodríguez-Pombo, Paula Esteiro Simón, André Campos Álvarez, Carmen Alvarez-Lorenzo, Abdul W Basit, Alvaro Goyanes

Abstract read
In one paragraph

Article in Biosensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Atheer AwadDepartment of Clinical, Pharmaceutical and Biological Sciences, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK.ORCID 0000-0001-5245-0570
Lucía Rodríguez-PomboDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-1028-2737
Paula Esteiro SimónDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
André Campos ÁlvarezFABRX Ltd., Henwood House, Henwood, Ashford TN24 8DH, UK.ORCID 0009-0005-5177-6081
Carmen Alvarez-LorenzoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-8546-7085
Abdul W BasitDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-5368-6603
Alvaro GoyanesDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID 0000-0002-3378-6797

Funding

Ministerio de Universidades FPU20/01245
6 · The paper itself

Abstract

In recent years, biosensors have emerged as a promising solution for therapeutic drug monitoring (TDM), offering automated systems for rapid chemical analyses with minimal pre-treatment requirements. The use of saliva as a biological sample matrix offers distinct advantages, including non-invasiveness, cost-effectiveness, and reduced susceptibility to fluid intake fluctuations compared to alternative methods. The aim of this study was to explore and compare two types of low-cost biosensors, namely, the colourimetric and electrochemical methodologies, for quantifying paracetamol (acetaminophen) concentrations within artificial saliva using the MediMeter app, which has been specifically developed for this application. The research encompassed extensive optimisations and methodological refinements to ensure the results were robust and reliable. Material selection and parameter adjustments minimised external interferences, enhancing measurement accuracy. Both the colourimetric and electrochemical methods successfully determined paracetamol concentrations within the therapeutic range of 0.01-0.05 mg/mL (R

Indexed as

Biosensing TechniquesDrug MonitoringSalivaSmartphoneAcetaminophenColorimetryElectrochemical TechniquesHumansAcetaminophencolorimetric and electrochemical biosensingdigital analysisdigitised medication analysismobile phone biosensor apppatient-centric diagnosticsportable point-of-care diagnosticsremote drug monitoringRGB profilingsalivary excretions and biological fluidssmartphone-driven analysis

Identifiers

PMID40136960
PMCPMC11940247

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.