Evidence map›Paper›PMID 40136710›Full record

ArticleCells2025

Efficacy of Deferoxamine Mesylate in Serum and Serum-Free Media: Adult Ventral Root Schwann Cell Survival Following Hydrogen Peroxide-Induced Cell Death.

Yee Hang Ethan Ma, Abhinay R Putta, Cyrus H H Chan, Stephen R Vidman, Paula Monje, Giles W Plant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yee Hang Ethan MaDepartment of Neuroscience and Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA.
Abhinay R PuttaDepartment of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.
Cyrus H H ChanDepartment of Neuroscience, The Ohio State University, Columbus, OH 43210, USA.
Stephen R VidmanDepartment of Neuroscience and Neuroscience Graduate Program, The Ohio State University, Columbus, OH 43210, USA.ORCID 0009-0007-7281-7959
Paula MonjeDepartment of Neurosurgery, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0002-5274-9238
Giles W PlantDepartment of Neuroscience and Chronic Brain Injury Program, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-7366-652X

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
NCI NIH HHS P30 CA016058The Ohio State University 125100
6 · The paper itself

Abstract

Schwann cell (SC) transplantation shows promise in treating spinal cord injury as a pro-regenerative agent to allow host endogenous neurons to bridge over the lesion. However, SC transplants face significant oxidative stress facilitated by ROS in the lesion, leading to poor survival. deferoxamine mesylate (DFO) is a neuroprotective agent shown to reduce H

Indexed as

DeferoxamineHydrogen PeroxideSchwann CellsAnimalsAutophagyCell DeathCell SurvivalCulture Media, Serum-FreeHypoxia-Inducible Factor 1, alpha SubunitOxidative StressRatsRats, Sprague-DawleyCulture Media, Serum-FreeDeferoxamineHydrogen PeroxideHypoxia-Inducible Factor 1, alpha Subunitdeferoxamine mesylateoxidative stressSchwann cellsspinal cord injurytransplantation

Identifiers

PMID40136710
PMCPMC11940984

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.