Evidence map›Paper›PMID 40136700›Full record

ArticleCells2025

Characterisation of Cytotoxicity-Related Receptors on γδ T Cells in Chronic Lymphocytic Leukaemia.

Michał Zarobkiewicz, Natalia Lehman, Izabela Morawska-Michalska, Adam Michalski, Wioleta Kowalska, Agata Szymańska, Waldemar Tomczak, Agnieszka Bojarska-Junak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michał ZarobkiewiczDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-0788-6353
Natalia LehmanDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-2324-5679
Izabela Morawska-MichalskaDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
Adam MichalskiDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0001-9598-373X
Wioleta KowalskaDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-0930-5874
Agata SzymańskaDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-3764-7452
Waldemar TomczakDepartment of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-080 Lublin, Poland.ORCID 0000-0002-3205-5781
Agnieszka Bojarska-JunakDepartment of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-2340-9442

Funding

National Science Center in Poland 2019/35/N/NZ6/02973
6 · The paper itself

Abstract

Chronic lymphocytic leukaemia (CLL) is a haematological malignancy primarily affecting older adults, characterised by the proliferation of functionally impaired B lymphocytes with abnormal expression of CD5, a typical T cell marker. The current study investigates the expression of cytotoxicity-related receptors (CD16, CD56, CD57, CD69) and a checkpoint (LAG-3) on γδ T cells in CLL patients. Sixty-nine treatment-naive CLL patients and fourteen healthy controls were recruited. Flow cytometry analysis revealed that the CLL patients had higher expressions of CD56 and LAG-3 and lower CD16 on their γδ T cells compared to the healthy controls. Subgroup analysis showed that ZAP-70-negative patients exhibited increased CD69, while CD38-negative patients showed higher CD16 expression. Additionally, CD16 expression was inversely correlated with serum LDH levels, a marker of disease progression. Bioinformatic analysis of the LAG-3 ligand mRNA in a CLL dataset indicated higher expression of

Indexed as

Intraepithelial LymphocytesLeukemia, Lymphocytic, Chronic, B-CellReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAgedAged, 80 and overAntigens, CDCase-Control StudiesFemaleHumansLymphocyte Activation Gene 3 ProteinMaleMiddle AgedAntigens, CDLag3 protein, humanLymphocyte Activation Gene 3 ProteinReceptors, Antigen, T-Cell, gamma-deltaCD16CD56CD57CD69chronic lymphocytic leukaemia (CLL)LAG-3γδ T cells

Identifiers

PMID40136700
PMCPMC11941621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.