Evidence map›Paper›PMID 40136535›Full record

ArticleBiology2025

Mitochondrial Proteome Reveals Metabolic Tuning by Restricted Insulin Signaling to Promote Longevity in

Xuanxuan Guo, Jiuwei Lu, Long Miao, Enzhi Shen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. A pilot study for whole proteome tagging inbioRxiv : the preprint server for biology · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xuanxuan GuoSchool of Medicine, Zhejiang University, Hangzhou 310058, China.
Jiuwei LuDepartment of Biochemistry, University of California Riverside, Riverside, CA 92521, USA.ORCID 0000-0002-6478-4081
Long MiaoKey Laboratory of RNA Biology, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Enzhi ShenSchool of Medicine, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-6095-7803

Funding

National Natural Science Foundation of China NSFC32070628Zhejiang Provincial Natural Science Foundation of China LR22C050003
6 · The paper itself

Abstract

Aging is a time-dependent process of functional decline influenced by genetic and environmental factors. Age-related mitochondrial changes remain incompletely understood. Here, we found that compared to the wild type, the mitochondria of long-lived

Indexed as

agingDAF-2metabolismmitochondriaquantitative proteomics

Identifiers

PMID40136535
PMCPMC11940386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.