Evidence map›Paper›PMID 40136429›Full record

ReviewCurrent issues in molecular biology2025

Innovation in Osteogenesis Activation: Role of Marine-Derived Materials in Bone Regeneration.

Maria Giovanna Rizzo, Marilena Briglia, Vincenzo Zammuto, Dario Morganti, Caterina Faggio, Federica Impellitteri, Cristiana Roberta Multisanti, Adriana Carol Eleonora Graziano

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Giovanna RizzoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166 Messina, Italy.
Marilena BrigliaDepartment of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.
Vincenzo ZammutoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166 Messina, Italy.ORCID 0000-0003-2382-5905
Dario MorgantiConsiglio Nazionale delle Ricerche DSFTM, Department of Physical Sciences and Technologies of Matter, Piazzale Aldo Moro, 7, 00185 Roma, Italy.ORCID 0000-0003-1682-1092
Caterina FaggioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166 Messina, Italy.
Federica ImpellitteriDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, 98168 Messina, Italy.ORCID 0000-0003-1694-2281
Cristiana Roberta MultisantiDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, 98168 Messina, Italy.ORCID 0000-0002-6283-2502
Adriana Carol Eleonora GrazianoDepartment of Medicine and Surgery, "Kore" University of Enna, 94100 Enna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine-derived biomaterials are emerging as promising candidates for tissue regeneration due to their sustainability, biocompatibility, bioactivity, and unique chemical structure. This review provides an overview of different marine-derived inorganic and organic materials, such as calcium carbonate, magnesium salts, silica, polysaccharides, bioactive peptides, and lipid-based compounds, and their effects in promoting osteogenesis. Specifically, the osteoinductive, osteoconductive, and osteointegrative activities of traditional and innovative materials that influence key molecular pathways such as BMP/Smad and Wnt/β-catenin signaling underlying bone formation will be evaluated. This review also prospects innovative approaches, i.e., phage display technology, to optimize marine-derived peptides for targeted bone regeneration. In the context of innovative and sustainable materials, this review suggests some interesting applications of unusual materials able to overcome the limitations of conventional ones and stimulate cellular regeneration of bone tissue by activating specific molecular pathways.

Indexed as

blue biotechnologiesbone tissue regenerationeco-physiologymarine biomaterialsmarine ecologymolecular pathways

Identifiers

PMID40136429
PMCPMC11941683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.