Evidence map›Paper›PMID 40136345›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Toward Timely and Equitable Advanced Biomarker Testing for Patients with Metastatic Cancer in Canada.

Brandon S Sheffield, Shantanu Banerji, Allen Chankowsky, Shaan Dudani, Sharlene Gill, Zuzanna Gorski, Shaqil Kassam, Cassandra Macaulay, Mita Manna, Kirstin Perdrizet and 3 more

Abstract readConference Proceedings
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brandon S SheffieldWilliam Osler Health System, Brampton, ON L6R 3J7, Canada.
Shantanu BanerjiRady Faculty of Health Sciences, Department of Medical Oncology and Hematology, University of Manitoba, CancerCare Manitoba, Winnipeg, MB R3E 0V9, Canada.ORCID 0000-0002-7531-1378
Allen ChankowskyPatient Advocate, Member of the ASCO TAPUR molecular tumour board, Toronto, ON, Canada.ORCID 0009-0006-3513-9338
Shaan DudaniWilliam Osler Health System, Brampton, ON L6R 3J7, Canada.
Sharlene GillBC Cancer Agency, Vancouver, BC V5Z 4E6, Canada.ORCID 0000-0003-3306-3617
Zuzanna GorskiAnatomical Pathology and Laboratory Medicine, QEII Health Sciences Centre, Halifax, NS B3H 1V8, Canada.
Shaqil KassamStronach Regional Cancer Centre, Newmarket, ON L3Y 2P9, Canada.
Cassandra MacaulayColorectal Cancer Resource & Action Network (CCRAN), Toronto, ON M4W 3E2, Canada.
Mita MannaSaskatoon Cancer Centre, Saskatoon, SK S7N 4H4, Canada.ORCID 0000-0003-4344-7913
Kirstin PerdrizetWilliam Osler Health System, Brampton, ON L6R 3J7, Canada.ORCID 0000-0002-8746-665X
Ravi RamjeesinghDivision of Medical Oncology, QEII Health Sciences Centre, Halifax, NS B3H 2Y9, Canada.ORCID 0000-0001-5584-3505
Monika Slovinec D'AngeloColorectal Cancer Resource & Action Network (CCRAN), Toronto, ON M4W 3E2, Canada.
Filomena Servidio-ItalianoColorectal Cancer Resource & Action Network (CCRAN), Toronto, ON M4W 3E2, Canada.ORCID 0009-0009-1079-2295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The explosion in biomarker testing over the past two decades continues to transform cancer care in Canada and around the world. Precision medicine is supported by identifying actionable mutations that direct therapeutic choices, thus improving survival and quality of life, especially for patients with advanced/metastatic disease. In addition, our growing understanding of the genetic basis of cancer is advanced by research employing ever-expanding databases of genetic mutations, therapies and outcomes. Despite this promising progress, however, access to biomarker testing remains inequitable across Canada, to the detriment of patients. Several underlying factors contribute to this situation, including the need for investment in and standardization of laboratory medicine infrastructure and processes, and the lack of suitable methods for cost/benefit evaluations to inform funding decisions. In 2024, a Canadian conference brought together patients, clinicians, researchers, policy-makers and scientists to address "Equitable Access to Advanced Biomarker Testing for Canadian Metastatic Cancer Patients". Two major themes arose from the conference: the urgent need to adopt comprehensive genomic profiling (CGP) as a standard of care across Canada, and the emerging role of liquid biopsy in accelerating access to biomarker testing for patients with advanced/metastatic cancer.

Indexed as

Biomarkers, TumorNeoplasmsCanadaHumansNeoplasm MetastasisPrecision MedicineBiomarkers, Tumorbiomarker testingcirculating tumor DNA (ctDNA)comprehensive genomic profilinggenomic medicinegenomic testingliquid biopsymolecular testingmutational testingnext generation sequencingprecision medicine

Identifiers

PMID40136345
PMCPMC11941070

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.